isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µm) to assess the changes in reactive oxygen species (ros) and lipid peroxidation leading to apoptotic hepatocyte cell death. the viability of hepatocytes was declined depending on the iron concentration. one hour incubation of the cells with 100 µm iron resulted in decreased...

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of potentially damaging levels of reactive oxygen species (ROS), Ca(2+), etc., which must be normalized. Evidence suggests that brief mitochondrial permeability transition pore (mPTP) openings play an important physiological role maintaining healthy mitochondria homeostasis. Adaptive and maladaptive responses to r...

the present study was designed to investigate the protective effect of ethanol extracts from lindera coreana leaves (lce) on uvb-induced oxidative stress in hacat keratinocytes. the hacat cells were pretreated with lce for 24 h and then exposed to uvb (20 mj/cm2) for 2 h. uvb significantly decreased the cell viability (p<0.05). lce did not exhibit significantly cytotoxic effects and increased t...

bronchial asthma is the common chronic inflammatory disease and is characterized by chronic airway inflammation, airway remodeling, and airway hyperreactivity (ahr). aim of this study was to investigate the effects of mitochondrial atp-sensitive potassium channels (mitokatp) on the proliferation and secretion of human airway smooth muscle cells (hasmcs). hasmcs were treated with the serum from ...

Isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µM) to assess the changes in reactive oxygen species (ROS) and lipid peroxidation leading to apoptotic hepatocyte cell death. The viability of hepatocytes was declined depending on the iron concentration. One hour incubation of the cells with 100 µM iron resulted in decreased...

Isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µM) to assess the changes in reactive oxygen species (ROS) and lipid peroxidation leading to apoptotic hepatocyte cell death. The viability of hepatocytes was declined depending on the iron concentration. One hour incubation of the cells with 100 µM iron resulted in decreased...

sperm is particularly susceptible to reactive oxygen species (ros) during critical phases of spermiogenesis. however, the level of seminal ros is restricted by seminal antioxidants which have beneficial effects on sperm parameters and developmental potentials. mitochondria and sperm plasma membrane are two major sites of ros generation in sperm cells. besides, leukocytes including polymer phonu...

BACKGROUND: The active oxygen species, despite the damaging effects they have useful roles in the body are living things. OBJECTIVES: This research was done to determine whether Reactive Oxygen Species (ROS) could mediate Cyanide and Methylviologen signal in seed dormancy alleviation and sunflower seed germination, more widely, to assess their putative ro...