Corneal biopsy specimens from 3 patients with Cogan's microcystic corneal dystrophy were examined by light and electron microscopy. Specimens were taken from corneas showing microcysts, geographic or map-like areas, and refractile striae. In all samples there is a bilaminate subepithelial layer of fibrogranular material, the friability of which is probably the basis for recurrent erosions in th...

Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered fr...

Cover illustration: Coat of arms and location of the two Swedish counties Småland (lat. Smolandia) and Hälsingland (lat. Helsingia or Helsinglandia) wherefrom the two corneal disorders described in this thesis originate. Published articles and figures have been reprinted with the permission of the copyright holders. To my family and in memory of my father Turmoil accompanies every great change....

AIMS Phototherapeutic keratectomy with an excimer laser is commonly used to treat recurrent corneal erosion syndrome. The aim of this study was to determine the success of a repeat phototherapeutic keratectomy for patients with persistent macroerosions following initial treatment with phototherapeutic keratectomy. METHODS Eight patients who failed primary phototherapeutic keratectomy for recu...

Recurrent epithelial erosions develop in the cornea due to prior injury or genetic predisposition. Studies of recurrent animal models allow us gain insight into how form and are resolved. While slowing corneal cell migration reducing their proliferation following treatment with mitomycin C reduce erosion formation mice after sterile debridement injury, additional factors have been identified re...

PURPOSE To report the observation of a triple corneal dystrophy association consisting of keratoconus (KC), epithelial basement membrane corneal dystrophy (EBMCD) and Fuchs' endothelial corneal dystrophy (FECD). METHODS A 55-year-old male patient was referred to our cornea service for blurred vision and recurrent foreign body sensation. He reported bilateral recurrent corneal erosions with di...