BACKGROUND/AIMS This study was designed to investigate risk factors related to asymptomatic erosive esophagitis and the natural history of both endoscopic findings and reflux-related symptoms in subjects with asymptomatic erosive esophagitis. MATERIALS AND METHODS On a retrospective basis, data were gathered from patients with erosive esophagitis (Los Angeles classification 3A) who had underg...

AIM To determine the prevalence and characteristics of bile reflux in gastroesophageal reflux disease (GERD) patients with persistent symptoms who are non-responsive to medical therapy. METHODS Sixty-five patients (40 male, 25 female; mean age, 50 +/- 7.8 years) who continued to report symptoms after 8 wk of high-dose proton pump inhibitor (PPI) therapy, as well as 18 patients with Barrett's ...

o r t R s h m f 3 o b Many new and exciting endoscopy-related studies on Barrett’s esophagus, reflux esophagitis, and eosinophilic esophagitis were presented during the 2012 Digestive Disease Week (DDW; 19-22 May, San Diego, California, USA). Endoscopic research in Barrett’s esophagus mainly focused on surveillance, detection, and ablation therapy, while clinical studies in eosinophilic esophag...

AIM Esophagitis is associated with an impaired esophageal peristalsis. A few studies have been aimed at understanding the pathophysiology of abnormal peristaltic activity. The mechanism of impaired esophageal smooth muscle reactivity in the chronic gastroesophageal reflux (GER) model is investigated in vitro for the first time. MATERIALS AND METHODS The chronic GER rat model was created by pa...

conclusions b. oleracea demonstrated similar anti-inflammatory properties to omeprazole in rats with gerd. however, omeprazole also demonstrated genotoxic and cytotoxic effects in rats without gerd. results rats with gerd developed esophagitis and esophageal squamous cell carcinoma. b. oleracea and omeprazole-treated gerd rats presented significantly decreased inflammation in relation to non-tr...

AIM The aim of this study was to evaluate risk factors for proton pump inhibitor (PPI) resistance in older Japanese female patients with reflux esophagitis evaluated by physicians. METHODS The study included 462 Japanese female patients aged over 60 years with reflux esophagitis who received PPI maintenance therapy for more than 6 months. RESULTS The characteristics of all 462 patients were...

CONTEXT Impairment of esophageal motility is a common finding in patients with gastroesophageal reflux disease (GERD) as reduced lower esophageal sphincter (LES) basal pressure. A very low LES pressure might facilitate the occurrence of more gastroesophageal reflux whereas abnormal esophageal peristalsis may contribute to impaired esophageal clearance after reflux. OBJECTIVE Evaluate the esop...

UNLABELLED BACKGROUND Our aim in the present study was to compare patients presenting with gastroesophageal reflux disease in the presence or absence of mild-grade esophagitis (grade I or II according to the Savary-Miller classification). METHODS Between 2005 and 2007, 215 patients with gastroesophageal reflux disease (67 with reflux associated with grade I or II esophagitis and 148 withou...

The clinical features of patients reflux esophagitis without any symptoms have not been clearly demonstrated. This study evaluated the clinical features of patients with endoscopy-positive reflux esophagitis, who did not complain of symptoms, as detected by brief questioning by nursing staffs. Eight thousand and thirty-one patients not taking medication for gastrointestinal disease, were briefl...

background: we sought to determine the clinical characteristics of pediatric esophagitis in southern iran. methods: this cross-sectional study was conducted over a 4-year period, from 2005 to 2009, in nemazee hospital, a tertiary healthcare center in shiraz, southern iran. we consecutively included all pediatric patients (< 18 years) who underwent endoscopy in our center and had pathology-co...