background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

The authors studied six patients with refractory temporal lobe epilepsy and postictal psychosis using quantitative MRI and histopathology, and compared the results with 45 patients with temporal lobe epilepsy without postictal psychosis. Total hippocampal volumes were not different between the two groups. However, patients with postictal psychosis had a relatively preserved anterior hippocampus...

New onset refractory status epilepticus (NORSE) is a relatively newly defined disease entity, where otherwise healthy individuals develop unrelenting seizures that do not respond to conventional anticonvulsant therapy and may require months of therapy with anesthetic drugs. We have described a case of NORSE who subsequently developed mesial temporal lobe sclerosis (MTS) and recurrent temporal l...

PURPOSE Focal cortical dysplasia (FCD) represents a common cause of refractory epilepsy. It is considered a sporadic disorder, but its occasional familial occurrence suggests the involvement of genetic mechanisms. METHODS Siblings with intractable epilepsy were referred for epilepsy surgery evaluation. Both patients were examined using video-EEG monitoring, MRI examination and PET imaging. Th...

The relationship between depression and epilepsy has been known since ancient times, however, to date, it is not fully understood. The prevalence of psychiatric disorders in persons with epilepsy is high compared to general population. It is assumed that the rate of depression ranges from 20 to 55% in patients with refractory epilepsy, especially considering those with temporal lobe epilepsy ca...

introduction : shared neuropathology hypothesis in schizophrenia and temporal lobe epilepsy has been introduced long term ago. similar neuropathology leads to the analogous clinical features like neuropsychological features as an example. the aim of this study was to examine this hypothesis by the means of comparing neuropsychological functions in these two patient groups. method : present stud...

background and objective: temporal lobe epilepsy (tle) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. this study was designed to assess the protective effe...

The combination of psychosis and refractory temporal lobe epilepsy is not rare. However, patients with chronic interictal psychosis and refractory epilepsy are rejected from many epilepsy surgery programmes purely on psychiatric grounds. It is often assumed that disturbed behaviour will prevent adequate preoperative evaluation or that the patients are unable to provide informed consent for preo...

The occurrence of de novo psychogenic seizures after epilepsy surgery is rare, and is estimated in 1.8% to 3.6%. Seizures after epilepsy surgery should be carefully evaluated, and de novo psychogenic seizures should be considered especially when there is a change in the ictal semiology. We report a patient with de novo psychogenic seizures after anterior temporal lobe removal for refractory tem...