the aim of this study was to investigate the effect of acute swimming stress on plasma corticosterone and leptin levels in female and male rats. thirty- seven adult male (n=20) and female (n=20) sprague dawley rats (200-250 g weight) were used. the leptin and corticosterone levels were measured following swimming stress (10 minutes) or no stress. plasma leptin and corticosterone were measured b...

background: obesity is pandemic worldwide and a strong risk factor for cardio-metabolic disorders. the few approved anti-obesity drugs have poor efficacy and safety profile. thus, there is an urgent need for new anti-obesity agents. according to the traditional medicine and a clinical trial, saffron may have anorexigenic and anti-obesity effects which need further investigation. objectives: eva...

In the adult brain, leptin regulates energy homeostasis primarily via hypothalamic circuitry that affects food intake and energy expenditure. Evidence from rodent models has demonstrated that during early postnatal life, leptin is relatively ineffective in modulating these pathways, despite the high circulating levels and the presence of leptin receptors within the central nervous system. Furth...

AIM To evaluate the changes in the expression level of gonadal steroid, insulin, and leptin receptors in the brain of adult Sprague-Dawley female rats due to ovariectomy and/or chronic stress. METHODS Sixteen-week-old ovariectomized and non-ovariectomized female Sprague-Dawley rats were divided in two groups and exposed to three 10-day-sessions of sham or chronic stress. After the last stress...

Abstract Leptin plays a major role in the regulation of energy intake and expenditure, triggering effects on several tissues, such as hypothalamic-pituitary-thyroid axis. The reported leptin thyroid are controversial, being mainly explored during imbalance. Therefore, aim this study was to evaluate function rats fed ad libitum distinguishing direct responses from those mediated by leptin-depend...

Background: Leptin, the hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety. In cattle, leptin has also been implicated in the control of ovarian function, but its local production in the ovary and role in the control of ovarian function in autocrine/paracrine manner is unknown. The aims of this study were to documen...

Background and Aim: Cessation of ovarian function is a major cause postmenopausal osteoporosis. Ovariectomized rats dogs have been used extensively in osteoporosis models. This study examined the effect Pueraria Radix isoflavone extract not only on Bone Mineral Density (BMD) but also bone strength using formation resorption markers ovariectomized as an model. Methods: The model (OVX) induced by...

It is well documented that the hormone leptin regulates many central functions and that hippocampal CA1 pyramidal neurons are a key target for leptin action. Indeed, leptin modulates excitatory synaptic transmission and synaptic plasticity at the Schaffer-collateral input to CA1 neurons. However the impact of leptin on the direct temporoammonic (TA) input to CA1 neurons is not known. Here we sh...

Background Olanzapine is an orexigenic antipsychotic drug associated with serious metabolic adverse effects in humans. Development of valid rodent models for antipsychotic-induced metabolic adverse effects is hampered by the fact that such effects occur in females only. Estradiol is a predominant female hormone that regulates energy balance. We hypothesized that the female-specific hyperphagia ...

Molecular-level understanding of body weight control is essential for combating obesity. We show that female mice lacking tyrosine phosphatase epsilon (RPTPe) are protected from weight gain induced by high-fat food, ovariectomy, or old age and exhibit increased whole-body energy expenditure and decreased adiposity. RPTPe-deficient mice, in particular males, exhibit improved glucose homeostasis....