The objectives of this study were (a) To Perform in-vitro release study of marketed Nifedipine formulation,(b) To check effect of integrity on release profiles, (c) To determine the possibility of switchover from one formulation to another formulation and (d) To compare release profiles with formulated batches by application of mathematical models. Four marketed and two prepared controlled rele...

population growth, industrial pollution and high-energy consumption, cause the release of significant amounts of pollutants in the environment. power plants play an important role in the release of pollutants such as sulfur dioxide, nitrogen oxides, and carbon dioxide. if the necessary measures in the field of prevention and control do not be implemented, human health and other living creatures...

the aim of this study was to develop a derivative of chitosan as pharmaceutical excipient used in sustained-release matrix tablets of poorly soluble drugs. a water-soluble quaternary ammonium carboxymethylchitosan was synthesized by a two-step reaction with carboxymethylchitosan (cmcts), decylalkyl dimethyl ammonium and epichlorohydrin. the elemental analysis showed that the target product with...

Current patient release criteria established in NRB-99/2009 relate to four radionuclides used Russia that period of the document preparation. These were calculated only considering radionuclide decay. Thus, these give conservative assessments which require stay dedicated protected room (“hot” room) radiotherapy department for several days and do not allow therapy be given outpatient hospital ce...

a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

in the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in f1 (1:0.75), f2 (1:1), f3 (1:1.5),...

hard gelatin capsule filled with acetaminophen, osmotic agent (sorbitol), a release promoter (sodium dodecyl sulfate), coated with a semipermeable cellulose acetate membrane containing a hydrophobic plasticizer (castor oil) and sealed with white bees wax plug was designed. when placed in the sink water penetrates the membrane, dissolves the osmotic agent and increases the osmotic pressure insid...