Based on a massive transcription factor location analysis within a single cell type, in this issue Yan et al. find that the great majority of occupancies occur within dense clusters of up to 100 factors that almost invariably contain cohesins. Retention of cohesins at cluster sites during mitosis raises the possibility that they contribute to transcriptional memory during the cell cycle.

In this issue of Cell, Rajasethupathy et al. report a surprising role for piRNAs, previously thought to act mainly in the animal germline to silence transposons, in transcriptional regulation of plasticity-related genes in the central nervous system of the sea slug Aplysia californica. The findings expand the functions of small RNAs and have important implications for our understanding of how t...

74 CASE REPORT 1 T his 63 year old Caucasian man with past medical history significant for hypertension, arthritis, prostate cancer status post radiation therapy, and a family history of colon and pancreatic cancer presented to the emergency department with right lower quadrant pain. The WBC count was 10.1, Hct 41, Plt 213, Amylase 34 and Lipase 83. CT scan of the abdomen revealed a dilated app...