BACKGROUND Outcomes after acute myocardial infarction in patients with chronic kidney disease are extremely poor. Ischemic conditioning techniques are among the most powerful cytoprotective strategies discovered to date. However, experimental data suggest that comorbidity may attenuate the protective effects of ischemic conditioning. METHODS AND RESULTS We conducted investigations into the ef...

Background—Outcomes after acute myocardial infarction in patients with chronic kidney disease are extremely poor. Ischemic conditioning techniques are among the most powerful cytoprotective strategies discovered to date. However, experimental data suggest that comorbidity may attenuate the protective effects of ischemic conditioning. Methods and Results—We conducted investigations into the effe...

RATIONALE Remote ischemic conditioning induced by repeated episodes of transient limb ischemia is a clinically applicable method for protecting the heart against injury at the time of reperfusion. OBJECTIVE To assess the effect of chronic, repeated, remote conditioning on infarct size and long-term remodeling after myocardial infarction. METHODS AND RESULTS Rats with ischemia/reperfusion in...

Off-pump coronary artery bypass surgery by avoiding cardioplegic arrest seems to reduce the risk of ischemic myocardial injury. However, even short-term regional ischemic periods, hemodynamic instability and arrhythmias associated with the procedure can be responsible for myocardial damage. Conditioning, a potential cardio-protective tool during on-pump cardiac surgery, has hardly been investig...

Aetna considers remote ischemic conditioning experimental and investigational for the treatment of aneurysmal subarachnoid hemorrhage, myocardial infarction, primary graft dysfunction following lung transplantation, spinal cord injury, traumatic brain injury, and other indications (e.g., for cardiac, cognitive, pulmonary and renal protection during cardiac surgery, endovascular aneurysm repair,...