oxygen-derived free radical* (ofr) involvement in ischacmia-rcpcrfusion (ir) injury was investigated in a rat isolated kidney model, using 20 minutes iscliaemia followed by 15 or 60 minutes reperfusion. two antioxidants, the xanthine oxidase inhibitor allopurinol and the hydroxyl radical scavenger dimcthylthiourca (dmtu), were uscit to try and prevent ofr-relatcd damage. renal function was esti...

Background Nephrotoxicity is a dose limiting side effect of Tenofovir (TDF), a commonly used anti-HIV drug. About 37-45% of patients on anti-HIV drugs suffer from renal damage. As the mechanism of pathogenesis of TDF induced renal damage is not clear, it is necessary to elucidate the mechanism in order to prevent the renal damage. This study investigates the roles of nitroso-oxidative stress an...

BACKGROUND Renal dysfunction was reported to be closely associated with clinical outcomes in patients with chronic heart failure (CHF). Renal tubulointerstitial damage has been shown to be an important factor in the development of renal dysfunction as well as glomerular damage. However, the impact of renal tubular damage on clinical outcomes in patients with CHF remains to be determined. METH...

hydroalcoholic extract (70% ethanol extract) of tubers of momordica tuberosa cogn. (cucurbitaceae) was subjected to preliminary phytochemical screening by qualitative tests. nitric oxide scavenging activity was performed by griess reagent method. and nephroprotective activity was assessed in gentamicin, cisplatin and paracetamol induced renal damage in wistar rats (150-200 g) by standard method...

Clinical data showed consumption of buckwheat played a very positive role in the relief of diabetes and its complications. The purpose of this study was to explore the effects and mechanisms of the overall flavonoids from buckwheat flowers and leaves (TFBFL) on renal damage in type 2 diabetes mellitus (T2DM) rats. Seventy male Wistar rats were selected. Ten rats were randomly allocated into a n...

objective(s) portulaca oleracea l. is a herbaceous weed from portulacaceae family. it can be found in many parts of the world. modern pharmacological studies have demonstrated that p. oleracea have antioxidant effects. the protective effect of aqueous and ethanolic extract of p. oleracea against cisplatin-induced renal toxicity was studied in rats. materials and methods single intraperitoneal i...

background and aims: post exercise proteinuria and increased urinary gamma-glutamyl transferase (ggt) levels can be indicative of exercise-induced renal damage. the aim of this investigation was to study the effect of one session of intensive training on renal tubular injury markers and compare their values to those 6 hours after training, for evaluating tubular damage after intensive training....

Background and Aims: Post exercise proteinuria and increased urinary Gamma-Glutamyl transferase (GGT) levels can be indicative of exercise-induced renal damage. The aim of this investigation was to study the effect of one session of intensive training on renal tubular injury markers and compare their values to those 6 hours after training, for evaluating tubular damage after intensive ...

Background: The application of methotrexate (MTX) as a chemotherapy agent and immune system suppressant has various side effects. Crocin, a xanthine derivative plant, has many therapeutic benefits. This study was planned to assess the effect of crocin on renal toxicity of MTX in a rat model. Methods: Forty eight rats were divided randomly into eight groups (n = 6), which received normal saline,...