BACKGROUND Death with a functioning graft (DWGF) is now one of the main causes of renal transplant (RTx) loss. AIM To determine whether the causes of DWGF, characteristics of donors and recipients and complications of RTx have changed in the last two decades. SUBJECTS AND METHODS Cooperative study of a cohort of 418 kidney grafts performed between 1968 and 2010. Patients were divided into t...

BACKGROUND The uremic milieu exposes chronic kidney disease (CKD) patients to premature ageing processes. The impact of renal replacement therapy (dialysis and renal transplantation [RTx]) or immunosuppressive treatment regimens on ageing biomarkers has scarcely been studied. METHODS In this study telomere length in whole blood cells was measured in 49 dialysis patients and 47 RTx patients cl...

BACKGROUND Peripheral chemoreceptors residing predominantly in the carotid body monitor changes in arterial blood oxygen and are mechanistically linked to the cardiorespiratory control by the autonomic nervous system. Enhanced sympathetic activation is common in end-stage renal disease and kidney transplantation has been shown to improve cardiorespiratory reflex measures of autonomic function. ...

The aim of the study was to evaluate changes in expression of PBP5 gene associated with immunosuppression. A linear locked nucleic acid (LNA) probe was used to measure resistance gene expression by the Flow-FISH method. Expression of the PBP5 gene measured by Flow-FISH was higher in enterococcal strains isolated from renal transplantation (RTx) recipients than in commensal strains. Additionally...

The two cancers after renal transplantation (RTx) are transitional cell carcinoma (TCC) and hepatoma reported in Taiwan most frequently, versus lymphproliferative diseases and skin cancers in the Western literature. Herein, we present a 49-year-old man with spinal cord injury and end-stage renal disease who developed multifocal TCC in the urologic tract and incidental detection of prostatic ade...

Abstract Background and Aims The pathophysiology of rejection after renal transplantation (RTx) has not been unraveled completely. In previous studies, Th17 cells were shown to be involved in several autoimmune diseases affecting the kidney, e.g. lupus nephritis, glomerulonephritis ANCA vasculitis. aim this study was decipher dynamics RTx with focus on IL17 cytokine family. Method For purpose, ...

results two weeks after transplantation, the mean tpe decreased to 0.052 ± 0.002, which was significant compared to pre-hd (p < 0.001) and post-hd (p = 0.019). the mean tpec was 0.059 ± 0.002, which, just in comparison to pre-hd, was significant (p = 0.005). in addition, the mean tpe/qt decreased to 0.143 ± 0.005, which was significant compared to pre-hd (p = 0.018). the mean qtd was 0.066 ± 0....

The 'weekend effect' describes increased adverse outcomes after weekend hospitalization. We examined weekend-weekday differences in the outcome of 580 patients following renal transplantation (RTx, brain dead donors) between January 2007 and December 2014 at our center. 3-year patient and graft survival, incidence of delayed graft function (DGF), acute rejections and estimated glomerular filtra...

BACKGROUND Patients with renal insufficiency often suffer from cachexia and growth retardation due to low appetite and increased resting metabolic rate. The neuroendocrine hormone ghrelin, a growth hormone secretagogue, enhances food intake, but its role in the development of a cachectic state in renal insufficiency is unclear. Objective. The aim of our study was to investigate the plasma conce...

Immunosuppression is the major risk factor for BK virus nephropathy (BKVN) after renal transplantation (RTx). As the individual tacrolimus (Tac) metabolism rate correlates with Tac side effects, we hypothesized that Tac metabolism might also influence the BKV infection risk. In this case-control study RTx patients with BK viremia within 4 years after RTx (BKV group) were compared with a BKV neg...