objective(s):bradykinin is a part of the kinin-kallikreinsystem which is involved in ischemia-reperfusion injury via b1 and b2 receptors.noscapine is a non-competitive antagonist of bradykinin receptors. noscapine has been reported to to be able to protect some organs against ischemia-reperfusion injury but its effect on renal ischemia-reperfusion injury (rir) in rats is unknown. therefore, the...

Despite the latest advances in cardiovascular biology and medicine, myocardial infarction (MI) remains one of major causes deaths worldwide. While reperfusion myocardium is critical to limit ischemic damage typical a MI event, it detrimental morphological functional changes known as “reperfusion injury.” This complex scenario poorly represented currently available models ischemia/reperfusion in...

To explore the protective effect of bilobalide on pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. simulate ischemia-reperfusion condition, was The cells were divided into control, and deprivation/ reperfusion+bilobalide groups. viability, proliferative capacity, malondialdehyde level, superoxide dismutase apoptosis, Wnt1 protein level nuclear beta-cateni...

ischemia-reperfusion injury is a possible cause of testicular damage and infertility after testicular torsion and detorsion. the purpose of this study was to evaluate the effect of ghrelin on testicular ischemia-reperfusion damage. a total of 30 adult male rats were selected for the study and divided randomly into 3 groups, each containing 10 rats. animals in the testicular torsion and ghrelin ...

Background: Renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. This study was performed to investigate the protective effects of different antioxidants such as vitamin C, vitamin E, hydrocortisone and combination of these agents against experimental renal ischemia-reperfusion injury....

the present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (i/r) injury in rats.forty male rats were randomly divided into sham, control (i/r injury) and three crocin-pretreated groups. to induce i/r lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. pretreated-rats rec...

Objective-Ovarian torsion must be diagnosed and treated as much early as possible. The aim of the present study was to investigate effects of interaperitoneal administration of curcumin on ischemia-reperfusion injury in ovaries. Design- Experimental Study Animals- Twent-four healthy female Wistar rats Procedures- Twent-four healthy female Wistar rats weighing approximately 260...

background myocardial injury caused by ischemia-reperfusion leads to cardiac dysfunction, tissue injury and metabolic changes. the production of reactive oxygen species (ros) and lipid peroxidation are accompanied by ischemia-reperfusion injury. objectives the aim of this study was to assess the cardio protective potential effects of crocin in comparison with vitamin e on antioxidant capacity i...

introduction: this study was designed to evaluate the effects of treatment with flaxseed oil (fso) on renal ischemia-reperfusion (rir) injuries in rats. materials and methods: in this study, 32 wistar rats were randomly studied in four groups: co+ns (control group with normal saline administration), sh+ns (sham group with normal saline administration), rir+ns and rir+fso. fso (0.2 ml) was admin...

Acute myocardial infarction (AMI) is the leading cause of death, morbidity, and health costs worldwide. In AMI, a sudden blockage blood flow causes ischemia cell death. Reperfusion after has paradoxical effects may exacerbate injury, process known as ischemic reperfusion injury. this work we evaluated lipidome isolated rat hearts, maintained in controlled perfusion (CT), undergoing global (ISC)...