The use of biomaterials to restore the function of traumatized or degenerated connective tissues and thus improve the quality of life of a patient has become widespread. In the past, implants were designed with insufficient cognizance of biomechanics. Accordingly, the clinical results were not very encouraging. An upsurge of research activities into the mechanics of joints and biomaterials has ...

We explore a new type of replacement of patterns in permutations, suggested by James Propp, that does not preserve the length of permutations. In particular, we focus on replacements between 123 and a pattern of two integer elements. We apply these replacements in the classical sense; that is, the elements being replaced need not be adjacent in position or value. Given each replacement, the set...

Chlorofluorocarbons (CFCs) are stable in the atmosphere and may reach the stratosphere. They are cleaved by UV-radiation in the stratosphere to yield chlorine radicals, which are thought to interfere with the catalytic cycle of ozone formation and destruction and deplete stratospheric ozone concentrations. Due to potential adverse health effects of ozone depletion, chlorofluorocarbon replacemen...

A new stratified approach to pre-clinical tribological simulation of joint replacements is presented, which extends beyond present standard conditions used. It includes variations in surgical delivery, variations in kinematics, variations in the patient population and degradation of the biomaterials technology. Examples of the new methods are presented, which have been validated against clinica...

We describe a novel freely available web server Base of Bioisosterically Exchangeable Replacements (BoBER), which implements an interface to a database of bioisosteric and scaffold hopping replacements. Bioisosterism and scaffold hopping are key concepts in drug design and optimization, and can be defined as replacements of biologically active compound's fragments with other fragments to improv...