Depressive disorder will be the second highest disease burden worldwide, which will impair life quality, reduce productivity, and increase disability and mortality. LBP is the main active fraction purified from Lycium barbarum. The aim of this study was to evaluate the potential therapeutic effects of LBP on depressive mice induced by reserpine, as well as the relevant mechanisms. The antidepre...

A single stillborn female with craniofacial, abdominal, and central nervous system malformations was exposed to reserpine during the first six weeks of gestation. Parallels between the malformations present in this infant and those induced in rats through exposure to reserpine at analogous periods of gestation suggest that reserpine may pose specific risks for malformations in some pregnancies.

Reserpine a well known phytochemical molecule found in the dried roots of plants such as Rauwolfia Serpentina and Rauwolfia Vomitoria. It is a hypertension drug molecule used in drug formulation. Reserpine ranks as one of the most complex natural product of its size and contains 21 skeletal atoms compactly arranged in five rings. The stereo chemical complexity and biological significance of Res...

BACKGROUND Reserpine, an alkaloid from Rauwolfia serpentina was widely used for its antihypertensive action in the past. In later years, its use has been reduced because of precipitation of depression and extra pyramidal symptoms due to its central action. In the present investigation, reserpine methonitrate (RMN), a novel quaternary analogue of reserpine was synthesised and evaluated biochemic...

Effects of ergocornine and reserpine on tail resorption during metamorphosis in Bufo bufo japonicus tadpoles were studied. At prometamorphosis, ergocornine induced precocious tail resorption, while reserpine scarcely affected the tail size. At the climax of metamorphosis, ergocornine was almost ineffective in accelerating tail resorption, while reserpine was effective in inhibiting tail resorpt...

A Streptococcus pneumoniae strain selected for resistance to ethidium bromide demonstrated enhanced energy-dependent efflux of this toxic dye. Both the ethidium resistance and the ethidium efflux could be inhibited by the plant alkaloid reserpine. The ethidium-selected cells demonstrated cross-resistance to the fluoroquinolones norfloxacin and ciprofloxacin; this resistance could also be comple...

Protection against anaphylactic shock in mice by reserpine has been shown to be a delayed phenomenon, probably not dependent upon a direct effect of reserpine. The release and depletion of catechol amines by reserpine show little likelihood of being responsible for protection because these substances are in themselves protective against anaphylactic shock, while beta-TM 10, a drug which interfe...

The effects of reserpine (catecholamine depletor) and LHRH analogues on gonadotropin secretion, spermiation and ovulation of common carp were investigated. Injections of reserpine alone at a dose of 1 or 7 mg/kg of body weight stimulated spermiation, and reserpine at a dose of 1 mg/kg of body weight in combination with (D-Arg6, Trp7, Leu8, Pro9, NEt)-LHRH (s-GnRH-A) or with (D-Ala6, Pro9)-LHRH ...

Effect of methanolic extract of Hibiscus rosa sinensis (100-300 mg/kg) was studied on reserpine-induced orofacial dyskinesia and neurochemical alterations. The rats were treated with intraperitoneal reserpine (1 mg/kg, ip) for 3 days every other day. On day 5, vacuous chewing movements and tongue protrusions were counted for 5 min. Reserpine treated rats significantly developed vacuous chewing ...

Investigations of the effect of pharmacological preparations on pulmonary hypertension in man are important for several reasons: from the potential therapeutic aspect; because these data may help to elucidate the regulation of pressure in the pulmonary artery; and finally because they may show whether pulmonary hypertension is reversible or irreversible. While the effect of reserpine on hyperte...