In this study, twenty-five strains of Mycobacterium tuberculosis resistant to isoniazid (INH) were isolated from patients with tuberculosis (TB). Nine strains (36%) were found to be virulent in guinea-pigs [root index virulence (RIV» 1 ]. The remaining sixteen strains (64%) were non-virulent (RIV <1). Of the nine strains resistant to INH as well as virulent to guinea-pigs, eight of them wer...

Tuberculosis remains a global emergency causing an estimated 1.5 million deaths annually. For several decades the major focus of tuberculosis treatment has been on antibiotic development targeting Mycobacterium tuberculosis. The lengthy tuberculosis treatment duration and poor treatment outcomes associated with multi-drug resistant tuberculosis (MDR-TB) are of major concern. The sparse new tube...

Introduction: Aloe vera has anti-bacterial ability against Gram-positive and Gram-negative bacteria; however, study, especially in multidrug resistant strain of Mycobacterium tuberculosis, not been evaluated yet. This study aims to determine the potential as an antituberculosis drug-resistant strains tuberculosis. Method: Stages research include production ethanol extract vera, then testing phy...

tuberculosis is one of the most important infectious diseases and a major cause of morbidity and mortality in developing countries. multi drug resistant tuberculosis is a new threat, which can result in a high case fatality rate. this study was conducted to define the incidence of multidrug resistant tuberculosis in kermanshah. ­antibiogram was performed on­­ pcr-confirmed isolates of mycobacte...

Treatment outcomes for adolescents with multidrug-resistant tuberculosis are rarely reported and, to date, have been poor. Among 90 adolescents from Lima, Peru, 68 (75.6%) achieved cure or completion of treatment. Unsuccessful treatment was less common in the Peru cohort than previously described in the literature.

conclusions review of the studies revealed that levels of multidrug-resistant tuberculosis among new tuberculosis patients are increasing in iran and the vaccination system needs to be reformed. because of the increasing number of patients coming from neighboring countries with multidrug-resistant tuberculosis, this area needs more stewardship and control in order to prevent the outbreak of mul...

Multidrug resistant tuberculosis has been a challenging situation in the clinical practice with respect to appropriate clinical treatment and management of the disease. The likelihood of resistance development is known to be lower in lesions with lesser percentages of the bacterial population. The present paper was designed to present a rare case of pulmonary multidrug resistant tuberculosis wi...

background: transmission of mycobacterium tuberculosis ( m. tuberculosis ) can occur in different ways. furthermore, drug resistant in m. tuberculosis family is a major problem that creates obstacles in treatment and control of tuberculosis (tb) in the world. one of the most prevalent families of m. tuberculosis is haarlem, and it is associated with drug resistant. our objectives of this study ...

The tuberculosis treatment control program is constrained by the outbreak of TB that resistant to anti-tuberculosis drugs (OAT), especially multidrug-resistant tuberculosis. Confirmation drug resistance really needs be done in each area considering there are variations phenotypes and genotypes region through laboratory tests such as molecular biology tests. Aim study determine prevalence Mycoba...

Multidrug-resistant tuberculosis (MDR) is perceived as a growing hazard to human health worldwide. Judgments about the true scale of the problem, and strategies for containing it, need to come from a balanced appraisal of the epidemiological evidence. We conclude in this review that MDR is, and will probably remain, a locally severe problem; that epidemics can be prevented by fully exploiting t...