The haemolytic activity of 5-«-alk(en)ylresorcinols is temperature dependent and correlated to their transition temperatures. The values of the parameters describing the 5-«-alk(en)ylresorcinol-induced red blood cell lysis indicate strong affinity of the compounds to the membrane and their high lytic capacity. The affinity of the compounds for the membrane decrease with the increasing quantity ...

henols and phenolic substances are aromatic hydroxy compounds classified as monohydric (e.g., phenol, cresols [methylphenols], xylenols [dimethylphenols]), dihydric (e.g., catechols [odihydroxybenzenes], resorcinols [m-dihydroxybenzenes]) or polyhydric (with three or more hydroxy groups), depending on the number of hydroxyl groups attached to the aromatic benzene ring (McNeely et al. 1979). The...

The haemolytic activity of 5-n-alk(en)ylresorcinols is temperature dependent and correlated to their transition temperatures. The values of the parameters describing the 5-n-alk(en)ylresorcinol-induced red blood cell lysis indicate strong affinity of the compounds to the membrane and their high lytic capacity. The affinity of the compounds for the membrane decrease with the increasing quantity ...

Eleven new bisresorcinols including four mixtures each of two isomers and one resorcinol/phloroglucinol derivative, together with five known resorcinols have been isolated from the ethyl acetate extract of stems of Grevillea whiteana. The new compounds were identified as 4-(3-hydroxy-3-methylbutyl)grebustol-B (10a), 4'-(3-hydroxy-3-methylbutyl)grebustol-B (10b), 4-(4-hydroxy-3-methylbutyl)grebu...

The fungal type III polyketide synthase 2'-oxoalkylresorcylic acid synthase (ORAS) primes with a range of acyl-Coenzyme A thioesters (C4-C20) and extends using malonyl-Coenzyme A to produce pyrones, resorcinols, and resorcylic acids. To gain insight into this unusual substrate specificity and product profile, we have determined the crystal structures of ORAS to 1.75 A resolution, the Phe-252-->...

The mucus layer acts as a selective diffusion barrier that has an important effect on the efficiency of drug delivery systems in human body. In this regard, currently nanocarriers various sizes and compositions are being widely developed to study their mucoadhesive properties i.e., ability interact with mucin. However, effective interaction composition mucin does not guarantee success due fact ...