Acute respiratory syncytial virus (RSV) bronchiolitis in children can result in sequelae of recurrent wheezing and asthma and production of RSV-specific immunoglobulin E (IgE), but the pathogenesis of these sequeleae is poorly understood. Guinea-pigs experimentally inoculated with human RSV show histological evidence of acute bronchiolitis and chronic persistence of viral antigens and genome in...

BACKGROUND Respiratory syncytial virus (RSV) is an established cause of serious lower respiratory disease in children, but the burden in adults is less well studied. METHODS We conducted a retrospective study of hospitalizations among adults ≥20 years from the 1997-2012 National Inpatient Sample. Trends in RSV admissions were described relative to unspecified viral pneumonia admissions. Hospi...

Respiratory syncytial virus (RSV) is a common winter time respiratory virus that affects persons of all ages. RSV was first isolated in children with pulmonary disease in 1957. Initially referred to as the ‘chimp coryza virus’, the nature of the virus to form syncytia (fusion of cells to form larger cells without any internal cell boundaries) in tissue culture subsequently resulted in the virus...

respiratory syncytial virus (rsv) is the major cause of lower respiratory tract infections in infants,and also an important factor for hospitalization during the winter months. to determine the prevalence and importance of rsv as a cause of acute lower respiratory tract infection, we carried out a prospective study during 5 months period from november to march 1998 in 6 pediatric hospitals. a n...

The mechanisms by which respiratory syncytial virus (RSV) infection induces bronchiolitis and airway disease are unclear. The presence of large numbers of polymorphonuclear leukocytes (PMN) in the airways of infants with RSV infection suggests a potential role of PMN in airway injury associated with RSV infection. To investigate the potential role of neutrophils in RSV bronchiolitis, human alve...

results in this study, seven sirna molecules were rationally designed against the nucleoprotein gene and validated using various computational methods for silencing different strains of rsv. additionally, three effective sirna molecules targeting the overlapping region of m2/l mrna were designed. conclusions this approach provides insight and a validated strategy for chemical synthesis of an an...

Respiratory syncytial virus (RSV) has been around for many years. Symptoms of the includes: cough, runny nose, loss appetite, and a possible ear infection. Often times, patient presents with bronchiolitis, which eventually escalates to RSV. Children most commonly affected by RSV are between ages 0-2. In December 2019, first case SARS-CoV-2 was discovered in China. Normally, sparks winter months...

Background and objective: COVID-19 pandemic reduced the incidence of many viral infections in children, raising concerns about future larger epidemics with easing containment measures. Respiratory syncytial virus (RSV) is a leading cause hospitalization infants aged

UNLABELLED A desirable vaccine against respiratory syncytial virus (RSV) should induce neutralizing antibodies without eliciting abnormal T cell responses to avoid vaccine-enhanced pathology. In an approach to deliver RSV neutralizing epitopes without RSV-specific T cell antigens, we genetically engineered chimeric influenza virus expressing RSV F262-276 neutralizing epitopes in the globular he...