The Lentivirus life replication cycle involves the synthesis of viral RNAs. These RNAs are divided in three groups: fully spliced, partially spliced and unspliced mRNAs. As described in HIV-1, the fully spliced viral mRNAs encode regulatory proteins including Tat and Rev whereas the partially spliced viral mRNAs produce enzymatic and structural proteins. The unspliced RNAs are template for geno...

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Adipose-derived stem cells (ASCs) are considered a great alternative source of mesenchymal stem cells (MSCs). Unlike bone marrow stem cells (BMSCs), ASCs can be retrieved in high numbers from lipoaspirate, a by-product of liposuction procedures. Given that ASCs represent an easily accessible and abundant source of multipotent cells, ASCs have garnered attention and curiosity from both scientifi...

Objective: To describe causes of orbital exenteration in a Brazilian tertiary hospital. Methods: A retrospective study was done, involving patients submitted to orbital exenteration at the Clinical Hospital of Botucatu Medical School, between the years of 1993 to 2016. The surgeries have been performed under general anesthesia, by a multidisciplinary team, composed by ophthalmologists, otolaryn...

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IS INSOMNIA A DISORDER OF AROUSAL? Prevalence of Insomnia Insomnia is the most common sleep disorder. Its prevalence varies according to the definition. One-fourth to one-third of the general population reports complaints of difficulty with falling and/or staying asleep whereas ten percent seek medical help for insomnia. Insomnia occurs more frequently with increasing age, in women, in patients...

Research on Astym therapy began with a multi-disciplinary research team theorizing about a potential physical treatment method with the ability to regenerate and remodel soft tissues. These theories were built upon emerging evidence regarding the degenerative nature of tendinopathy, and the investigations into how cellular mediators and growth factors may enhance healing. Hypothesizing that an ...