.37. Boileau C, Martel-Pelletier J, Brunet J, et al. Oral treatment with PD-0200347, anα2δ ligand, reduces the development ofexperimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. Arthritis Rheum. 2005 Feb;52(2):488-500.38. Pelletier JP, Lascau-Coman V, Jovanovic D, et al. Selectiv...

10. Nam JL, Ramiro S, Gaujoux-Viala C, Takase K, Leon-Garcia M, Emery P, et al. Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2014, doi: 10.1136/annrheumdis-2013-204577. [Epub ahead of print]. 11. Dhillon S. Intravenous Tocilizumab: A R...

view of scoring methods, their reliability and applicability. Baillieres Clin Rheumatol 1996;10:435–53. 2. Kuper HH, van Leeuwen MA, van Riel PL, Prevoo ML, Houtman PM, Lolkema WF, et al. Radiographic damage in large joints in early rheumatoid arthritis: relationship with radiographic damage in hands and feet, disease activity, and physical disability. Br J Rheumatol 1997;36:855–60. 3. Cranney ...

the effects of ethanolic and aqueous extracts of rheum ribs l. (rr) of the family polygonaceae was studied on serum cholesterol concentration in rabbits. to induce hypercholesterolemia, 0.5 g/kg/day of pure cholesterol powder was given orally to each rabbit for two weeks then cholesterol was halved and each group of animals was treated with a different regimen for another two weeks. both the et...

rheum turkestanicum janischew. (polygonaceae) is a plant that grows in central asia and in north-east of iran. traditionally, people use roots of r. turkestanicum as an anti-diabetic and anti-hypertensive as well as anticancer agent. in this study the cytotoxicity and apoptogenic properties of ethyl acetate (etoac), n-hexane and h2o extracts from rheum turkestanicum janischew. (polygonaceae) ro...

widely known as a purgative and anti-inflammatory agent. In Chinese Pharmacopoeia, the official Dahuang is prescribed as the dried rhizome and root of Rheum palmatum L., R. tanguticum MAXIM. ex BALF., and R. officinale BAILLON of the family Polygonaceae. On the other hand, the Japanese Pharmacopoeia prescribes not only the above three species but also R. coreanum NAKAI, and their interspecific ...

Objectives: Trichomoniasis is one of the most common sexually transmitted diseases in humans and is caused by the protozoan Trichomonas vaginalis. Nowadays, increasing resistance to drugs such as metronidazole resulted in many problem, so new effective remedies are needed. In this study, we evaluate constituents of essential oil and anti-trichomonas activity of Rheum ribes. Materials and Method...

The cytochrome P450 protective activity of Sapindus mukorossi and Rheum emodi were evaluated against CCl4 induced prolongation of pentobarbitone sleep time in Wister rats. The fractions, at a dose of 0.2 g/kg,0.4g/kg p.o., Sapindus mukorossi, Rheum emodi significantly prevents the CCl4 induced prolongation of pentobarbitone sleep time (P<0.01), indicating the cytochrome P450 protection activity...

In recent years, large controlled trials have tested several new agents for systemic lupus erythematosus (SLE). Unfortunately, none of these trials has met its primary outcome. This does not mean progress has not been made. In fact, a great deal has been learned about doing clinical trials in lupus and about the biological and clinical effects of the drugs being tested. Many of these drugs were...

MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat Genet 2005;37:486–94. 4 Yazdani-Biuki B, Brickmann K, Wohlfahrt K et al. The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients. Arthritis Res Ther 2006;8:R97. 5 Orozco G, Robledo G, Linga Reddy MV et al. Study of the role of a func...