Abstract The influence of block forms on the shear behaviour soil–rock mixtures with soft blocks (soft S–RMs) can be efficiently investigated by discrete element method (DEM) basis accurate 3D models accounting for breakage. This paper proposes a novel modelling approach, based spherical harmonics series, generation geometries different but same convexity and angularity. An already existing non...

propranolol (pl), a non-selective beta-blocker, is a cardiovascular drug widely used to treat hypertension. the present study was concerned with assessing the cytogenetic effects of this drug on chinese hamster ovary (cho) cell line. mtt assay was then carried out to determine the cytotoxicity index (ic50) of the drug. the ic50 value of pl was 0.43±0.02 mm. to investigate the clastogenic effect...

PURPOSE Retinal detachment disrupts the rod-bipolar synapse in the outer plexiform layer by retraction of rod axons. We showed that breakage is due to RhoA activation whereas inhibition of Rho kinase (ROCK), using Y27632, reduces synaptic damage. We test whether the ROCK inhibitor fasudil, used for other clinical applications, can prevent synaptic injury after detachment. METHODS Detachments ...

The purpose of this study is to measure the size distribution of blasted rock using the digital image processing software “SplitDesktop system” in order to evaluate the efficiency of blasting operation. Site of study is a limestone quarry producing limestone for cement manufacturing. Fragmentation is the ultimate measure of efficiency of any production blasting operations. The degree of fragmen...

7 8 Key points 9-Compaction band instabilities due to cataclasis and dissolution in rocks 10-Strong chemo-poro-mechanical coupling, grain breakage and chemical softening 11-Regions of instability, compaction band thickness and periodicity 12 13 Abstract 14 During compaction band formation various mechanisms can be involved at different scales. 15 Mechanical and chemical degradation of the solid...

The first step in mining activities is rock excavation in both mine development and production. Constant pressure for cost reduction and creating an improved/safe work environment for personnel has naturally resulted in increased use of mechanical excavation systems in many mining operations. Also, mechanical excavation and mining is more compatible with automation, meaning possibility of reduc...