Background & Aims: With regard to the neuroprotective effect of creatine in some neurological disorders like cerebral ischemia, this study was conducted to evaluate the effect of creatine in an experimental model of Parkinson’s disease (PD). Involvement of oxidative stress was also assessed. Methods: In this experimental study, male rats (n = 40) were divided into 5 groups, i.e. sham-operated (...

Although segmental tunnel linings are often used for seismic areas, the influence of segment joints on the segmental lining behavior under seismic loading has not been thoroughly considered in the literature. This paper presents the results of a numerical study investigating the effects of the rotational, axial, and radial joint stiffness of the longitudinal joints on the structural force...

Opioids modulate brain dopaminergic function in various experimental paradigms. This study used the rotational model of behavior in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway to investigate this interaction. Doses of two presynaptically acting dopaminergic drugs, amphetamine and cocaine, were coadministered with several doses of the mu opioid agonist, mo...

Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. L-dihydroxyphenylamine (L-DOPA) therapy is currently the gold standard maneuver for PD. Due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this age...

According to the wide application of segmental lining in mechanized tunneling, recognizing the behavior of segmental lining joints is important in tunnels designing. In the structural analysis of the tunnel segmental lining, segmental joints can be considered as elastic joints, and their stiffness characteristics are affected by the rotational, shear, and axial stiffness. The purpose of this wo...

Cultured human catecholaminergic and non-catecholaminergic donor cells were used in neural transplantation experiments in a rat model of Parkinson's disease. Using two different human catecholaminergic neuroblastoma cell lines, one control non-catecholaminergic neuroblastoma cell line, and one sham control (tissue culture medium), transplants were made into the striatum using a modified Ungerst...

Rotational motion of heated 72Ge is studied within the microscopic shell-model Monte Carlo approach. We investigate the angular momentum alignment and nuclear pairing correlations associated with J^{π} Cooper pairs as a function of the rotational frequency and temperature. The reentrance of pairing correlations with temperature is predicted at high rotational frequencies. It manifests itself th...

Estrogen rapidly enhances dopamine (DA) activity in the striatum and nucleus accumbens as well as behavioral responses to psychomotor stimulants in female rats but not males. This experiment was conducted to investigate the role of pulsatile estrogen treatment on and sex differences in the development and expression of sensitization of cocaine-induced rotational behavior in rats with unilateral...