نتایج جستجو برای: rs1333049
تعداد نتایج: 62 فیلتر نتایج به سال:
مقدمه: بیماری عروق کرونری قلب (cad) بیماری چند عاملی و هتروژنیک است که در آن تشکیل پلاک های آترواسکلروزیس در دیواره ی داخلی عروق کرونر، میزان خون رسانی به میوکارد را محدود می کند. این امر ممکن است به بروز علائم ایسکمی، ترومبوز ناگهانی عروق و سکته ی قلبی منجر شود. این بیماری شایع ترین بیماری قلبی به شمار می رود بطوریکه بیش از 65000 نفر در کشور آمریکا در سال 2008 بر اثر بیماری های قلبی-عروقی مانن...
OBJECTIVE Coronary artery disease (CAD) is a multi-factorial and heterogenic disease with atherosclerosis plaques formation in internal wall of coronary artery. Plaque formation results to limitation of the blood reaching to myocardium leading to appearance of some problems, such as ischemia, sudden thrombosis veins and myocardial infarction (MI). Several environmental and genetic factors are i...
Atherosclerosis is one of the most important coronary artery disease (CAD) caused by lipid accumulation, hypertension, smoking, and many other factors such as environmental and genetic factors. It has been recorded that genetic variations in rs10757278 and rs1333049 are correlated with CAD. In the present study, 100 blood samples were collected (50 CAD patients and 50 appeared to be healthy con...
OBJECTIVE To examine variants at the 9p21 locus in a case-control study of acute myocardial infarction (MI) in Pakistanis and to perform an updated meta-analysis of published studies in people of European ancestry. METHODS AND RESULTS A total of 1851 patients with first-ever confirmed MI and 1903 controls were genotyped for 89 tagging single-nucleotide polymorphisms at locus 9p21, including t...
BACKGROUND Recent genome-wide studies have shown a significant association of a locus on chromosome 9p21.3 and coronary artery disease. We performed a case-control study to investigate the association between this locus and abdominal aortic aneurysm (AAA). METHODS AND RESULTS A total of 1714 patients (899 patients with AAA and 815 controls) were genotyped for the lead single-nucleotide polymo...
objective: coronary artery disease (cad) is a multi-factorial and heterogenic disease with atherosclerosis plaques formation in internal wall of coronary artery. plaque formation results to limitation of the blood reaching to myocardium leading to appearance of some problems, such as ischemia, sudden thrombosis veins and myocardial infarction (mi). several environmental and genetic factors are ...
foroughmand et al. (1) have recently reported association between coronary artery disease (cad) and two well-known single nucleotide polymorphisms (snps) on chromosome 9p21.3 in subjects from south-west iran. we doubt the validity of their findings. genotyping was done using arms-pcr for rs1333049 and rs10757274 in their study. when we first looked at the genotype frequencies, we observed a sub...
BACKGROUND Genome-wide association studies have recently identified a locus on chromosome 9p21 that influences risk of coronary artery disease (CAD). The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD). METHODS AND RESULTS We genotyped 2277 individuals, age 24...
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