نتایج جستجو برای: rs9939609 polymorphism

تعداد نتایج: 107470  

2016
Iwona Rotter Karolina Skonieczna-Żydecka Danuta Kosik-Bogacka Grażyna Adler Aleksandra Rył Maria Laszczyńska

PURPOSE Metabolic disorders, including MetS, obesity, and lipid disorders, may be related to genetic factors. Metabolic disorders are associated with decreased TS levels in aging men. The aim of this study was to evaluate the relationship between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the presence of MetS and its components, the concurrent lipid disorders, as well...

Journal: :Egyptian Journal of Medical Human Genetics 2022

Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine–metabolic disorder due to genetic and environmental factors. Genetic variants located in intron 1 of Fat mass obesity-associated ( FTO ) gene are associated with increased risk obesity metabolic disorders. This study aims investigate the association polymorphism rs9939609 South Indian women PCOS assess its endocrine para...

Journal: :Jornal de pediatria 2016
Cézane Priscila Reuter Miria Suzana Burgos Joana Carolina Bernhard Debora Tornquist Elisa Inês Klinger Tássia Silvana Borges Jane Dagmar Pollo Renner Andréia Rosane de Moura Valim Elza Daniel de Mello

OBJECTIVE To determine the association between overweight/obesity in schoolchildren with FTO rs9939609 polymorphism (fatmass and obesity associated) and family history of obesity. METHODS Cross-sectional study comprising a sample of 406 children aged 7-17 years in a city in southern Brazil. Overweight/obesity in schoolchildren was assessed by body mass index (BMI), and family history of obesi...

Journal: :Diabetes 2008
Lu Qi Kihwa Kang Cuilin Zhang Rob M. van Dam Peter Kraft David Hunter Chih-Hao Lee Frank B. Hu

OBJECTIVE To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. RESEARCH DESIGN AND METHODS We genotyped rs9939609 in 2,287 men and 3,520 women from two prospective cohorts. Plasma adiponectin and leptin were measured in a subset of diabetic men (n = 854...

2013
Nir Eynon Emiliya S. Nasibulina Lauren K. Banting Pawel Cieszczyk Agnieszka Maciejewska-Karlowska Marek Sawczuk Elvira A. Bondareva Roza R. Shagimardanova Maytal Raz Yael Sharon Alun G. Williams Ildus I. Ahmetov Alejandro Lucia Ruth Birk

OBJECTIVE The FTO A/T polymorphism (rs9939609) is a strong candidate to influence obesity-related traits. Elite athletes from many different sporting disciplines are characterized by low body fat. Therefore, the aim of this study was to assess whether athletic status is associated with the FTO A/T polymorphism. SUBJECTS AND METHODS A large cohort of European Caucasians from Poland, Russia and...

Journal: :Diabetes 2008
Camilla H Andreasen Kirstine L Stender-Petersen Mette S Mogensen Signe S Torekov Lise Wegner Gitte Andersen Arne L Nielsen Anders Albrechtsen Knut Borch-Johnsen Signe S Rasmussen Jesper O Clausen Annelli Sandbaek Torsten Lauritzen Lars Hansen Torben Jørgensen Oluf Pedersen Torben Hansen

OBJECTIVE Three independent studies have shown that variation in the fat mass and obesity-associated (FTO) gene associates with BMI and obesity. In the present study, the effect of FTO variation on metabolic traits including obesity, type 2 diabetes, and related quantitative phenotypes was examined. RESEARCH DESIGN AND METHODS The FTO rs9939609 polymorphism was genotyped in a total of 17,508 ...

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2012
W Luczynski G Zalewski A Bossowski

The phenomenon of excessive body mass increase in the general population of children and adults in the past few decades and has been attributed to environmental changes, especially when superimposed on a predisposing genetic background. The fat mass and obesity-associated (FTO) gene has recently become one of the most extensively investigated genes associated with body mass. The aim of the stud...

2014
Min Yang Yuyang Xu Li Liang Junfen Fu Feng Xiong Geli Liu Chunxiu Gong Feihong Luo Shaoke Chen Chunxiao Xu Dandan Zhang Zhengli Li Shuai Zhang Yan Zhang Hao Wang Yimin Zhu

The association of the rs9939609 single nucleotide polymorphism in FTO gene with obesity has been extensively investigated in studies of populations of European, African, and Asian ancestry. However, inconsistent results have been reported in Asian populations, and the relationship of FTO variation and dietary behaviors has only rarely been examined in Chinese children and adolescents. The aim ...

Journal: :International journal of clinical and experimental medicine 2015
Shan Xiao Xiaoyun Zeng Li Quan Jun Zhu

BACKGROUND To explore the correlation between FTO (fat mass and obesity associated) gene, which is associated with 3 single nucleotide polymorphisms (SNP) of fat mass and obesity, type 2 diabetes and body mass index (BMI) in the Uygur population in northwest China. METHODS A total of 849 Uygur patients with type 2 diabetes mellitus were selected from the hospitalized patients in the First Aff...

2018
Małgorzata Szkup Aleksander Jerzy Owczarek Daria Schneider-Matyka Jacek Brodowski Beata Łój Elżbieta Grochans

INTRODUCTION Metabolic syndrome (MetS) is regarded as a set of abnormalities, increasing the risk of serious functioning disorders. It can develop as a result of genetic predisposition. AIM The aim of this study was to establish associations between MetS-related abnormalities and the PPAR-γ rs1801282, FTO rs9939609, and MC4R rs17782313 polymorphisms. MATERIAL AND METHODS The study involved ...

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