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fungal sinus infections are being recognized with increasing frequency. we report a case with rhino cerebral and chest phaeohyphomycosis infection caused by cladosporium bantianum in an 18 year old man with wegener's granulomatosis. the diagnosis was established by histopathological appearance, direct examination, culture and computerized tomography (ct) scan. this case was successfully tr...

1 Rosen MJ. Dr. Friedrich Wegener, the ACCP, and history. Chest 2007; 132:739–741 2 Mitcham S. Why Hitler? Westport, CT: Praeger Publishing, 1996 3 Woywodt A, Haubitz M, Haller H, et al. Wegener’s granulomatosis. Lancet 2006; 367:1362–1366 4 Woywodt A, Matteson EL. Wegener’s granulomatosis: probing the untold past of the man behind the eponym. Rheumatology (Oxford) 2006; 45:1303–1306 5 Strous R...

concurrence of interstitial nephritis and uveitis named tubulointestitioal nephritis and uveitis syndrome (tinu) are unusual and uncommon presentations of interstitial nephritis. this syndrome is considered after ruling out other differential diagnoses. a-38-year old man presented with acute renal failure and uveitis. the histologic findings of renal biopsy showed acute tubulointestitioal nephr...

INTRODUCTION We describe the case of a woman with an unusual presentation of Wegener's granulomatosis. CASE PRESENTATION A 20-year old Caucasian woman presented with the principal feature of a pancolonic, superficial microulceration mimicking severe ulcerative colitis. Our patient was refractory to therapy and had persisting signs of septic shock as well as being at risk of perforation, so we...

The causes of multiple pulmonary nodules in a pediatric patient include infections, malignancies, sarcoidosis, granulomatosis with polyangiitis (GPA; formerly Wegener’s granulomatosis), eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg Strauss), hypersensitivity pneumonitis, and lymphomatoid granulomatosis. The clinician is faced with the challenging task of combining clinical...

Proteinase 3(PR3) is a human polymorphonuclear leukocyte serine proteinase and is the main target antigen for antineutrophil cytoplasmic antibodies (ANCA) found in Wegener's granulomatosis (WG). We developed a stable expression system for conformationally intact recombinant PR3 (rPR3) in Chinese hamster ovary cells (CHO-cells). The part of PR3 cDNA that encoded the active form of PR3 was s...