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The literature references are not grouped but appear at the end of each of the 384 sections. The book abounds with useful summaries and tables. While certain subjects, such as antibody-dependent cell-mediated cytotoxicity, are explained in great detail, others (suppressor T-cells, for example) receive comparatively short shrift. And although much of the material is timely, the section on drug-i...

ment of cancer are better understood than any genes which relate to the physical phenotype of Down syndrome. The causes of the mental retardation remain unelucidated, but the Alzheimer disease-related genes are discussed as possibilities. The creation of mouse models and the study of the existing mouse model based on partial trisomy of mouse chromosome 16 offer many exciting avenues for researc...