Correspondence: LaraFerrándiz,PhD,DermatologyUnit, Hospital Universitario Virgen Macarena, Avenue Dr Fedriani s/n, 41073 Seville, Spain ([email protected]). Author Contributions: Drs Ferrándiz and MorenoRamirez had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Acquisition of data: Ferrándiz, Ruizde-Casa...

Alzheimer's disease is a major public health problem in the world. Alzheimer's disease is a progressive, complex and heterogeneous neurodegenerative disorder. There are two types of Alzheimer's disease: familial Alzheimer's disease (FAD, also known as early onset Alz-heimer's disease) and sporadic type (also known as late onset Alzheimer's disease; LOAD). FAD is relatively rare, accounting for ...

BACKGROUND Echinococcus granulosus is a cestode whose larval stage causes cystic echinococcosis in wild animals, livestock, and human. OBJECTIVE The aim of this study is to highlight the seroepidemiology of E. granulosus infection and surgical cases in the general population of Khorram Abad district, southwest of Iran. MATERIALS AND METHODS Anti-E. granulosus antibodies were tested in 617 i...

A major obstacle to the development of effective treatment of Alzheimer's disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid-β peptide with amyloid-β binding alcohol dehydrogenase (ABAD). A selective and sensitive method for the presence of three new benzothiazole ABAD i...

Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

In a Perspective accompanying Abad-Franch and colleagues, Lorenz von Seidlein, Alexander Kekulé, and Daniel Strickman discuss the importance of developing effective strategies to minimize mosquito-borne transmission of human diseases.

BACKGROUND Since Pars Abad district had been known as a focus of visceral leishmaniasis (VL) in Ardabil Province but the prevalence of the disease in nomadic tribes has not been determined, thus, this study was conducted. METHODS This descriptive cross-sectional study was conducted on children up to 12yr old of nomadic tribes from Pars Abad County, Ardabil Province, Iran in 2015. For each ind...

In the acute setting, the majority of patients affected by uncomplicated acute type B aortic dissection (ABAD) can be managed with medical therapy. In these patients, inhospital outcome is generally acceptable, with mortality rates of 1-10% (1,2). However, long-term outcomes in this group is less positive, with a mortality rates reported as 2025% within 3 years. Predictors of long-term complica...