BACKGROUND Bronchodilators have been reported to influence regional lung ventilation in patients with chronic obstructive pulmonary disease (COPD), which may change regional lung sound distribution. Vibration response imaging (VRI) is a lung imaging system for the assessment of breath sounds. OBJECTIVE To evaluate the effects of a short-acting β2-agonist (SABA) on the regional distribution of...

BACKGROUND Bronchodilators are used for managing the symptoms of chronic obstructive pulmonary disease (COPD) and minimizing the risk of hospitalization and readmission. Hospital readmission is predictive of morbidity and mortality. OBJECTIVE The study objective was to compare all-cause readmission risk in COPD patients receiving nebulized long-acting β2-agonists (neb-LABAs) versus nebulized ...

S.Tartakover-Matalon1,5, N.Cherepnin1, M.Kuchuk2, L.Drucker1,4, I.Kenis2, A.Fishman3,4, M.Pomeranz3 and M.Lishner1,2,4 Oncogenetic Laboratory, Department of Medicine, Department of Obstetrics & Gynecology, Meir Medical Centre, Kfar-Saba and Sackler Faculty of Medicine, Tel–Aviv University, Israel To whom corresponding should be addressed at: Oncogenetic Laboratory, Meir Medical Centre, 45 Tsher...

background the importance of sialic acid binding adhesin (saba) as a new outer membrane protein in gastroduodenal diseases has been recognized. the prevalence rate of saba gene varies in different geographic areas. objectives the aim of this study was to determine the frequency of saba gene in helicobacter pylori (h. pylori) strains isolated from different clinical outcomes in tehran, iran. pat...

Modern high-performance processors access the branch target buffer (BTB) every cycle to speculate branch target addresses. This aggressive approach improves performance as it results in early identification of target addresses. However, unfortunately, such accesses, quite often, are unnecessary as there is no control flow instruction among those fetched. In this work we introduce Speculative BT...

BACKGROUND Understanding factors associated with the inappropriate or excessive use of short-acting beta agonists (SABA) can help develop better policies. METHODS We used British Columbian (BC)'s administrative health data (1997-2014) to create a retrospective cohort of asthma patients aged between 14 and 55 years. The primary and secondary outcomes were, respectively, inappropriate and exces...

A recent molecular phylogeny of the Arid clade of the genus Hemidactylus revealed that the recently described H. saba and two unnamed Hemidactylus species from Sinai, Saudi Arabia and Yemen form a well-supported monophyletic group within the Arabian radiation of the genus. The name 'Hemidactylus saba species group' is suggested for this clade. According to the results of morphological compariso...

BACKGROUND Adherence to asthma long-term controller medications is one of the key drivers to improve asthma management among patients with persistent asthma. While suboptimal use of controller medications has been found to be associated with more frequent use of oral corticosteroids (OCS), few studies exist regarding the relationship between adherence to controller therapy and the use of short-...

Novel, cellular, gain-of-signal, bioluminescent reporter assays for fatty acid synthesis type II (FASII) inhibitors were constructed in an efflux-deficient strain of Pseudomonas aeruginosa and based on the discovery that FASII genes in P. aeruginosa are coordinately upregulated in response to pathway disruption. A screen of 115,000 compounds identified a series of sulfonamidobenzamide (SABA) an...