Nervous system of Periplaneta americana cockroach is used in a wide range of pharmacological studies, including electrophysiological techniques. This paper presents its role as a preparation in the development of toxinological studies in the following electrophysiological methods: double-oil-gap technique on isolated giant axon, patch-clamp on DUM (dorsal unpaired median) neurons, microelectrod...

Members: Dr. Anuj Maheshwari, Dr. Banshi Saboo, Dr. B. M. Makkar, Dr. C. R. Anand Moses, Dr. Ch. Vasanth Kumar, Dr. J. Jayaprakashsai, Dr. Jayant Panda, Dr. K. R. Narasimha Setty, Dr. P. V. Rao, Dr. Rajeev Chawla, Dr. Rakesh Sahay, Dr. Samar Banerjee, Dr. Sanjay Agarwal, Dr. Sanjay Kalra, Dr. S. R. Aravind, Dr. Sujoy Ghosh, Dr. Sunil Gupta, Dr. S. V. Madhu, Dr. Vijay Panikar, Dr. Vijay Viswanathan

Just as the 19th century closed with the 1899 First International Peace Conference, held in The Hague, the Netherlands, calling for a ban on certain weapons, such as dum dum bullets and chemical gases, so is the 20th century coming to an end with the entering into force of the Ottawa Treaty banning antipersonnel landmines. What is remarkable about the two agreements is that they were created th...

Obesity impacts most of the population, and many countries are predicted to raise prevalence adults affected by obesity (OB) related disorders during recent decades. OB is uninterruptedly increasing at a shocking proportion throughout globe scattering as an epidemic threatening world health. It currently projected that more than 250 million population worldwide obese, comparable 7% adult popula...

Intact drugs with spirocyclopropylhexadienone moieties can be regenerated from the covalent DNA adducts induced by antitumor antibiotics duocarmycin (DUM) A, SA and some DUMA analogues in neutral aqueous solution. We detected the reversible nature of DUMs by determination of the antimicrobial activity and cytotoxicity of DUM-DNA adducts. All of the adducts selectively inhibited the growth of a ...

With the advances in communication technology, large volumes of information can transfer across continents within a fraction of a second. Nevertheless, computer users still suffer from unpleasant situations when they interact with systems and are required to adapt to systems rather than the other way round. User modeling aims to overcome this problem by enabling computer systems to interact wit...