نتایج جستجو برای: sag1

تعداد نتایج: 216  

Journal: :The Journal of biological chemistry 2010
Joanna Crawford Erika Lamb James Wasmuth Ognjen Grujic Michael E Grigg Martin J Boulanger

Toxoplasma gondii, the etiological agent of toxoplasmosis, utilizes stage-specific expression of antigenically distinct glycosylphosphatidylinositol-tethered surface coat proteins to promote and establish chronic infection. Of the three infective stages of T. gondii, sporozoites are encapsulated in highly infectious oocysts that have been linked to large scale outbreaks of toxoplasmosis. SporoS...

Journal: :The Journal of infectious diseases 2000
C W Angus D Klivington-Evans J P Dubey J A Kovacs

Immunization with DNA can induce humoral and cell-mediated immune responses, both of which are important in conferring immunity to Toxoplasma gondii. The efficacy of genetic vaccination with a cDNA encoding the T. gondii SAG1 (P30) surface antigen was evaluated. Sera of immunized mice showed recognition of T. gondii tachyzoites by immunofluorescence and exhibited high titers of antibody to SAG1...

2015
Muqing Cao Jue Ning Carmen I Hernandez-Lara Olivier Belzile Qian Wang Susan K Dutcher Yanjie Liu William J Snell

The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing organelles. Recently, we showed that cilium-generated signaling in Chlamydomonas induced rapid, anterograde IFT-independent, cytoplasmic microtubule-de...

2014
Khadijeh Khanaliha Mohammad Hossein Motazedian Bahram Kazemi Bahador Shahriari Mojgan Bandehpour Zarin Sharifniya

Serologic tests are widely accepted for diagnosing Toxoplasma gondii but purification and standardization of antigen needs to be improved. Recently, surface tachyzoite and bradyzoite antigens have become more attractive for this purpose. In this study, diagnostic usefulness of 3 recombinant antigens (SAG1, SAG2, and SAG3) were evaluated, and their efficacy was compared with the available commer...

Journal: :Veterinary parasitology 2008
N Sundar R A Cole N J Thomas D Majumdar J P Dubey C Su

Sea otters (Enhydra lutris) have been reported to become infected with Toxoplasma gondii and at times succumb to clinical disease. Here, we determined genotypes of 39 T. gondii isolates from 37 sea otters in two geographically distant locations (25 from California and 12 from Washington). Six genotypes were identified using 10 PCR-RFLP genetic markers including SAG1, SAG2, SAG3, BTUB, GRA6, c22...

Journal: :Infection and immunity 2003
Valerie Letscher-Bru Alexander W Pfaff Ahmed Abou-Bacar Denis Filisetti Elisabeth Antoni Odile Villard Jean-Paul Klein Ermanno Candolfi

We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds. In BALB/c mice (H-2(d)), vaccination reduced the number of infected fetuses by 50% and was associated with a mixed type 1 and type 2 immunity. In CBA/J mice (H-2(k)), vaccination increased the number of infected fetuses by 50% and was ass...

2014
Nahid ZAINODINI Mohammad ZARE-BIDAKI Seyyed Hossein ABDOLLAHI Mohammadreza AFROOZ Naser ZIAALI Mohammad EBRAHIMIAN Mohammad KAZEMI ARABABADI

BACKGROUND The differentiation between acute and latent forms of the Toxoplasma gondii (T. gondii) infection is still considered as a complicated issue. This study was aimed to elucidate the status of infection in the blood donors and the probable importance of blood transfusion in the transmission of the infection through detecting both immunological and genetic markers of acute and latent inf...

Journal: :Infection and immunity 1999
H V Nielsen S L Lauemøller L Christiansen S Buus A Fomsgaard E Petersen

Infection with the protozoan parasite Toxoplasma gondii is transmitted to humans from infected animals by tissue cysts and oocysts excreted by cats. Immunization with inactivated parasites or recombinant proteins has at best shown partial protection. We constructed a plasmid expressing the SAG1 surface antigen of T. gondii, p1tPASAG1, and showed that animals immunized with the plasmid produce a...

Journal: :Journal of immunology 2004
Nicolas Rachinel Dominique Buzoni-Gatel Chaitali Dutta Franck J D Mennechet Souphalone Luangsay Laurie A Minns Michael E Grigg Stanislas Tomavo John C Boothroyd Lloyd H Kasper

The role of specific microbial Ags in the induction of experimental inflammatory bowel disease is poorly understood. Oral infection of susceptible C57BL/6 mice with Toxoplasma gondii results in a lethal ileitis within 7-9 days postinfection. An immunodominant Ag of T. gondii (surface Ag 1 (SAG1)) that induces a robust B and T cell-specific response has been identified and a SAG1-deficient paras...

2013
Érica Araújo Mendes Flavio G. Fonseca Bárbara M. Casério Janaína P. Colina Ricardo Tostes Gazzinelli Braulia C. Caetano

The use of recombinant viral vectors expressing T. gondii antigens is a safe and efficient approach to induce immune response against the parasite and a valuable tool for vaccine development. We have previously protected mice from toxoplasmosis by immunizing the animals with an adenovirus expressing the protein SAG1 (AdSAG1) of T. gondii. We are now looking for ways to improve the vaccination s...

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