INTRODUCTION Although rare, salicylate intoxication through the skin should not be ignored as it can be severely life-threatening. We describe an original case of accidental poisoning with salicylates topically applied to the scalp of a 6-week-old infant. CLINICAL REPORT A 6-week-old infant, with no prior history, was admitted to the pediatric intensive care unit for treatment of severe disor...

Microbial metabolic pathway engineering is a potent strategy used worldwide to produce aromatic compounds. We drastically rewired the primary of Escherichia coli aromatics and their derivatives. The E. was compartmentalized into production energy modules. focused on pyruvate-forming reaction in biosynthesis some compounds as connecting those strains were engineered show no growth unless pyruvat...

3. Liver mitochondria isolated after suspension in 5 mM-sodium salicylate in 0-44m-sucrose carried out oxidative phosphorylation nearly as efficiently as the controls. 4. Salicylate was taken up by mitochondria at 00, but the binding was extremely labile. From 78 to 95 % of the salicylate taken up was removed by one rapid wash in sucrose medium. 5. The intracellular fluid of the livers of sailc...

BACKGROUND Salicylate self poisoning is potentially fatal. Plasma salicylate concentrations can be used to guide management when taken in the context of clinical features of toxicity and acid base status. Previous studies in the USA and Hong Kong have shown that routine measurement of plasma salicylate concentrations in all overdose patients is inappropriate, but there have been no previous stu...

there have been numerous efforts to formulate insulin into an oral dosage form. the major problems involved with the oral administration of insulin are acidic and enzymatic decomposition by the gastric medium, and poor absorption in the small intestine due to its macromolecular structure. this study attempted to test the enhancing ability of two absorption enhancers, sodium glycocholate (na-gc)...

1. Sodium salicylate modifies the precipitation of normal rabbit serum protein by sodium tungstate, and partially inhibits the precipitation of horse serum euglobulin by rabbit antiserum. Sodium salicylate added to a system containing crystalline egg albumin and its antibody partly prevents the formation of precipitate, the degree of inhibition being related to the concentration of salicylate. ...

Sodium salicylate and acetylsalicylic acid are drugs used as anti-inflammatory agents. Salicylate prevents nuclear factor-kappa B activation and can cause apoptosis. However, salicylate, a substrate of CYP2E1, is also an antioxidant and can scavenge reactive oxygen species. Experiments were carried out to evaluate whether salicylate can modulate CYP2E1-dependent toxicity. Addition of a polyunsa...

BACKGROUND AND PURPOSE Aspirin or its metabolite sodium salicylate is widely prescribed and has many side effects. Previous studies suggest that targeting neuronal receptors/ion channels is one of the pathways by which salicylate causes side effects in the nervous system. The present study aimed to investigate the functional action of salicylate on glycine receptors at a molecular level. EXPE...

in the study of the effects of salicylate on population density of naphthalene degrading bacteria and heterotrophic bacteria in a sample or: soil polluted with aromatic hydrocarbons, two different concentrations of salicylate (16, 160) ?g / gr of soil incubated for 30 days. at 160 ?g / gr, salicylate enhanced the density of naphthalene degraders and heterotrophic bacteria for 30 days. no chenge...

Complexes of yttrium(III) formed with 5-sulphosalicylic acid, 5-SSA (H3L), and 5-nitrosalicylic acid, 5-NSA (H2L), were investigated in 0.1 mol.dm −3 sodium perchlorate ionic medium at 25.0 ± 0.1 ◦C potentiometrically for various molar ratios of Y(III) to these salicylic acid, SA (H2L), derivatives. Y(III) forms YL and YL3− 2 type complexes with 5-SSA that have rather high stabilities (log β1= ...