While high-throughput genotyping technologies are becoming readily available, the merit of using these technologies to perform genome-wide association studies has not been established. One major concern is that for studies of complex diseases and traits, the whole-genome approach requires such large sample sizes that both recruitment and genotyping pose considerable challenge. Here we propose a...

background and purpose: sample size and its determination is one of the most important problems in health researches. calculating sample size for prevalence studies is one of the common questions of sample size topics. minimum sample size with least complexity is desirable in order to achieve the basic goal of these studies. this study aims to compare two formulas of sample size calculation for...

A statistical model developed from scientific theory may “fail to fit” the available data if the scientific theory is incorrect or if the sample size is too small. The former point is obvious but the latter is more subtle. In the latter case, the hypothesized model may fail to fit in the sense that it is viewed as unnecessarily complicated, and so the investigators settle upon a simpler model t...

Procedures are reviewed and recommendations made for the choice of the size of a sample to estimate the characteristics (sometimes known as parameters) of a population consisting of discrete items which may belong to one and only one of a number of categories with examples drawn from forensic science. Four sampling procedures are described for binary responses, where the number of possible cate...

In experiments designed to estimate a binomial parameter, sample sizes are often calculated to ensure that the point estimate will be within a desired distance from the true value with sufficiently high probability. Since exact calculations resulting from the standard formulation of this problem can be difficult, "conservative" and/or normal approximations are frequently used. In this paper, so...

The paper presents a new method of sample size determination (SSD) based on performance evaluation of systems under study. The method builds upon previous work on Bayesian approach to nonparametric receiver operating characteristics (ROC) analysis with estimation of probability density functions and confidence intervals for parameters of ROC curve. Technical details of the method together with ...