Artificially regulating gene expression is an important step in developing new treatment for system-level disease such as cancer. In this paper, we propose a method to regulate gene expression based on sampled-data measurements of gene products concentrations. Inherent noisy behaviour of Gene regulatory networks are modeled with stochastic nonlinear differential equation. To synthesize feed...

Based on the synchronous language elements introduced in Modelica 3.3, a library is described to utilize the new features in a convenient way for graphical model definition of sampled data systems. The library has elements to define periodic clocks and event clocks that trigger elements to sample, subsample or super-sample partitions synchronously. Optionally, quantization effects, computationa...

YY filter, named after the founder Prof. Yutaka Yamamoto, is a digital filter designed by sampled-data control theory, which can optimize the analog performance of the signal processing system with AD/DA converters. This article discusses problems in conventional signal processing and introduces advantages of the YY filter.

In this paper we investigate the closed-loop performance of a sampled-data control system by utilizing exact discretization techniques. In particular, for an H2 performance measure we give exact expressions for the closed-loop cost for a given sample interval h. After applying discrete-time LQG synthesis to the sampled-data system, the achievable performance is evaluated for fast sampling near ...

a cochlear implant is an implanted electronic device used to provide a sensation of hearing to a person who is hard of hearing. the cochlear implant is often referred to as a bionic ear. this paper presents an undecimated wavelet‑based speech coding strategy for cochlear implants, which gives a novel speech processor. the undecimated wavelet packet transform (uwpt) is computed like the wavelet ...

the complexity of splitting a single fullrate signal into third octave sections. The complexity of a single PQMF cosine modulated lter bank (analysis or synthesis), C QMF (M; N) is on the order of N+MlogM M , where N is the length of the lowpass prototype lter and M is the number of channels in the lter bank. The M in the denominator is because of the dec-imation by M, N is the cost of FIR conv...

Hidden Markov models (HMM’s) have been used to model single channel currents as recorded with the patch clamp technique from living cells. Continuous time patch-clamp recordings are typically passed through an antialiasing filter and sampled before analysis. In this paper, an adaptation of the Baum-Welch weighted least squares (BW-WLS) algorithm called the H-noise algorithm is presented to esti...