In our study, it was aimed to create a new drug delivery system by loading the chemotherapeutic drugs into exosome vesicles. This act as Trojan horse targeting GBM cancer. Exosomes were isolated from T-98G cell line and characterized. encapsulated with Temozolomide. Then, effectiveness of this evaluated using MTT, LDH, TAC, TOS, GR. 
 MTT results show dose-dependent decrease in TMZ Exolime...

The protective effects of aqueous extracts of the fruit rind of Garcinia indica (GIE) on ethanol-induced hepatotoxicity and the probable mechanisms involved in this protection were investigated in rats. Liver damage was induced in rats by administering ethanol (5 g/kg, 20% w/v p.o.) once daily for 21 days. GIE at 400 mg/kg and 800 mg/kg and the reference drug silymarin (200 mg/kg) were administ...

In this paper we present a decoder architecture for variable-length codes capable of decoding alternated coded Golomb-Rice (GR) Codes in parallel. An architecture developed specifically for GR-codes and a coding method, we call alternating coding, simplify the decoder structure and enable parallel decoding. The proposed decoder detects the codeword lengths for all codewords in the input buffer ...

OBJECTIVE To evaluate predicting factors and prevalence of meningitis in patients with first seizure and fever aged 6-18 months old. METHODS This cross-sectional study was performed on 800 patients aged 6-18 months old who had first attack of seizure with fever between March 2005 and March 2012 in the pediatric ward of Ghaem Hospital, Mashhad, Iran. RESULTS Among 800 patients, lumbar punctu...

Phlebotomine sand flies are distributed across nearly all faunal regions of the world, represented by over 800 species, of which many are important vectors of human pathogens. Brazil is currently faced with the expansion and urbanization of leishmaniases, with an increase in the numbers of human cases and seropositive dogs in various medium-sized to large cities. The objective of the current st...

0TUse of lignocellulosic biomass as an alternative, renewable and sustainable source of energy has fulfilled part of the growing demand for energy in developed countries. Amongst various technologies applied to convert biomass wastes to biofuel and bioenergy, biomass gasification has attracted considerable attention. In this work, gasification of palm empty fruit bunch as a potential lignocellu...

GR99060 and GR99062 are representatives of a series of 1,2,4-triazino[5,6-b]indole compounds. This series possessed broad-spectrum antifungal activity in vitro. The MIC ranges of the two compounds were as follows: 0.25 to 4 micrograms/ml for Candida albicans, 0.25 to 16 micrograms/ml for Candida sp., 1 to 8 micrograms/ml for Aspergillus spp., and 0.25 to 16 micrograms/ml for Cryptococcus neofor...

b ac k gr o und: w o lbachia pipientis is maternally inherited endoparasitic bacterium belonging to the α-proteobacteria, infecting 20–75% of all insect species including sand flies. the wolbachia surface protein ( wsp ) was employed as an appropriate marker for strain typing. the objective of our research was to find the possibility of detection of w. p ipientis in phlebotomus perfiliewi trans...

Abstract Octopus fishing activity have been established in Ampana Waters and surrounding areas since the 1990s. The goal of this research is to examine octopus fishery waters its surroundings. methodology used study are CPUE Length-based assessment which includes some analysis catch per unit effort, season, size structure, weigh distribution, length-weight relationship, ground, gear operation s...

Given the current huge generation of solid waste worldwide, alternative and innovative methodologies for incorporating these materials should be encouraged elsewhere. In this context, objective research is to evaluate use glass as a substitute sand raw material in ceramics. Formulations containing from 0% 20% were produced, thus replacing natural sand. Extruded calcined specimens produced at te...