Advances in the theory of combination therapy (1) and development of new targeted drugs are leading to a new emphasis on drug combination experiments. Many studies continue to use the median-effect method of Chou–Talalay (2). However, the median-effect method follows a similar logic to the defunct Scatchard analysis in pharmacology, which has been replaced by nonlinear modeling. Like Scatchard ...

Fyfe, W. M., Hall, Margaret S., and Scott, Janet W. (1970). Archives of Disease in Childhood, 45, 84 Lipaemia retinalis in untreated diabetes mellitus. A 6-year-old girl developed diabetes mellitus, with marked hyperlipaemia and lipaemic retinalis, both of which rapidly cleared after insulin treatment. Biochemical studies led to the conclusion that dietary fat was the chief source of the excess...

Abstract In this work, the adsorption of ciprofloxacin onto yam peel biosorbent was studied by batch method. The equilibrium isotherm analysis process evaluated to provide insight into removal mechanism. A decrease in percentage (75.0 – 60.8%) and an increase capacity (6.0 24.3 mg/g) with concentration from 20 100 mg/L obtained. analyzed Langmuir, Temkin, Freundlich, Scatchard models, best fit ...

Disclosures: Jeffrey Abrams: None; Robert Erwin: Consultant/advisory role: Member CALGB DSUB (unpaid); member ASCO Research Committee (unpaid); Gwen Fyfe: None; Richard L. Schilsky: None. The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this a...

In this issue of Pediatrics, Fyfe et al present convincing evidence that cerebral tissue oxygenation index (TOI) is lower in habitually supinesleeping preterm infants placed prone rather than supine, and that the cerebral TOI for preterm infants placed prone is lower than the TOI for term infants placed prone. Increased rates of sudden infant death syndrome (SIDS) among all infants sleeping pro...

When we use Scatchard analysis for insulin receptor on intact cells, internalization of insulin may affect the Scatchard analysis. In this study, results from Scatchard analysis for insulin receptor on hepatocytes of streptozotocin (STZ)-induced diabetic rats were compared with those from association and dissociation studies and those from Scatchard analysis using hepatocyte membrane which does...

Nonlinear Scatchard plots are often found for agonist binding to G-protein-coupled receptors. Because there is clear evidence of receptor dimerization, these nonlinear Scatchard plots can reflect cooperativity on agonist binding to the two binding sites in the dimer. According to this, the "two-state dimer receptor model" has been recently derived. In this article, the performance of the model ...

women with HER2 positive MBC. Proc Am Soc Clin Oncol 2003; 22: (Abstr 294). 3. Fyfe GA, Mass R, Murphy M et al. Survival benefit of trastuzumab (Herceptin) and chemotherapy in older (age >60) patients. Proc Am Soc Clin Oncol 2001; 20: (Abstr 189). 4. Serrano C, Cortés J, De Mattos-Arruda L et al. Trastuzumab related cardiotoxicity in the elderly: a role for cardiovascular risk factors. Ann Onco...