background: the vegf is essential in the process of tissue remodeling and angiogenesis. limited data is available on the expression and regulation of vegf and its receptors in the human endometrium. the aim of this study was evaluation of expression patterns of vegf and flk-1 in human endometrium during the menstrual cycle. methods: sixty paraffin-embedded blocks of endometrial tissues from the...

results there was a significant increase (p < 0.05) in leptin levels on day 14 (12.75 + 5.8 ng/ml) and day 21 (12.91 + 3.2 ng/ml) for age group 18-30 years compared to day 14 (11.60 + 3.2 ng/ml) and day 21 (11.60 + 3.2 ng/ml) for age group 31-40 years. leptin was positively correlated with fsh on day 14, with lh on day 7 and day 21; likewise, with progesterone on day 21 and day 28 and with estr...

Angiogenin, a potent inducer of angiogenesis, is expressed in human endometrium. This study was performed to compare the expression of angiogenin mRNA level in the eutopic endometrium from women with and without endometriosis. Thirty-two women with advanced stage endometriosis and 29 control women were recruited. Following isolation of total RNA from endometrial tissue and reverse transcription...

The baboon oviductal epithelium differentiates into a tall columnar epithelium consisting of ciliated and secretory cells during the follicular phase of the menstrual cycle in response to rising oestradiol levels. The apical tips of these secretory cells are filled with membrane-bound secretory granules. During the luteal phase when progesterone levels are elevated, the epithelium regresses and...

The recently identified trans-membrane G protein-coupled estrogen receptor 1 (GPER, GPR30) has been implicated in rapid non-genomic effects of estrogens. This focuses on expression and localization of GPER mRNA and protein in normal cyclic endometrium and early pregnancy decidua. Real-time PCR, western blotting, in situ hybridization and immuno-histochemistry were used. Endometrial expression o...

in the secretory phase (Fig. 1C). Dysmorphic erythrocytes (morphologically variable) have been reported to be a marker for glomerular bleeding and isomorphic erythrocytes (morphologically uniform) for nonglomerular bleeding (2 ). The present study revealed that most erythrocytes in the menstrual phase are isomorphic but that all erythrocytes detected in the other phases are dysmorphic, suggesti...

BACKGROUND To test our hypothesis that eutopic secretory phase endometrium from women with endometriosis is similar to proliferative phase endometrium from fertile women without endometriosis, we explored the expression of regulators of cell fate across the menstrual cycle. METHODS Endometrial biopsies were taken from 73 women, comprising 38 women with surgically diagnosed active peritoneal e...

PRL expression in the human uterus is up-regulated during the mid to late secretory phase of the menstrual cycle. This coincides with up-regulation of the expression of the PRL receptor, which is localized primarily to the endometrial glandular epithelial cells. Recent data have demonstrated activation of the Jak (Janus kinase)/Stat (signal transducer and activator of transcription) signaling p...

The Present study attempts to determine the relationship between proliferation and inhibition of apoptosis in normal endometrium hyperplasia, using monoclonal antibodies against marker, Ki-67 anti-apoptotic protein, Bcl-2 expression B-cell lymphoma 2 (Bcl – 2) Ki 67 cyclical proliferative secretory phase. includes Bcl endometrial hyperplasia.