Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to respond to inflammatory or infectious etiologies and are crucial participants in the proper functioning of both innate and adaptive immune responses. From their initial appearance in the liver, thymus, and spleen at around the eighth week of human gestation to their generation in large numbers in the bone...

Hematological abnormalities were investigated in 13 cats with myelodysplastic syndrome (MDS). Examination of the peripheral blood samples from the 13 cats revealed anemia in 11 cats, leukopenia in 9 cats, and thrombocytopenia in 9 cats. Four cats had pancytopenia (30.8%) and 9 cats had bicytopenia (69.2%). Dysplastic changes of erythrocytes, neutrophils, and platelets in the peripheral blood we...

statement of problem: papillon lefevre syndrome (pls) is a rate autosomal recessive disorder, which is characterized by palmar- plantar hyperkeratosis and rapid periodontal destruction of primary and permanent dentitions. purpose: the aim of the present study was to evaluate the peripheral blood neutrophil function including random locomotion, chemotaxis and oxidative mechanism of killing in a ...

Polymorphonuclear neutrophilic leukocytes (PMNL) play a pivotal role during inflammation. Bone marrow (BM) reserves are depleted as cells are released into circulation for recruitment to infection sites. Expression of L-selectin on the cell membrane allows neutrophils to roll along the activated endothelium. Whereas mechanisms leading to recruitment to infection sites are well established, expr...

A 72-year old man was admitted to the hospital with a fever as high as 39°C; mild dyspnea; and tender, erythematous, vesicular skin lesions on his lower legs, forearms, and neck (Fig 1). A chest radiograph showed patchy consolidation in the right upper, right lower, and left lower lobes. Medical history was remarkable for a 1-year history of myelodysplastic syndrome. On admission, his hemoglobi...

T HE PRESENCE of alkalimse plsosphatase its segmented neutrophils has been well established. Although the origin, msature amid fumiction of this enzyme are poorly umsderstood, variations from the miornial leukocytic alkaline phosphatase activity have been demonstrated by biochensical amsd histoehemical methods. In chronic myelogemsous leukemia the emszynse is greatly deficient whereas its neutr...

A patient with metastatic soft tissue sarcoma presented with a leukemoid reaction. The elevated white blood cell count was due to an increase in bands and mature segmented neutrophils. The degree of granulocytosis correlated with the tumor burden. There was no evidence of superimposed infection and the degree of bone marrow involvement by metastatic tumor was minimal. A cell line derived from t...

Interrupted Time Series (ITS) analysis represents a powerful quasi-experime-ntal design in which a discontinuity is enforced at a specific intervention point in a time series, and separate regression functions are fitted before and after the intervention point. Segmented linear/quantile regression can be used in ITS designs to isolate intervention effects by estimating the sudden/level change (...

In the past differentiation of human neutrophils has been defined by morphology, cytochemistry, or surface markers. In our experiments we have sequenced the various events that occur during the functional differentiation of the normal human neutrophil and have also examined some of the functional properties in relationship to surface markers and biochemical events. Granulocytes were obtained fr...