Seamless integration of biological components with electrochemical sensors is critical in the development of microdevices for cell analysis. The present paper describes the integration miniature Au electrodes next to immune cells (macrophages) in order to detect cell-secreted hydrogen peroxide (H(2)O(2)). Photopatterning of poly(ethylene glycol) (PEG) hydrogels was used to both immobilize horse...

In this study the sensing capabilities of a combination of metals and conducting polymer electrodes for drinking water and dissolved tastants using an AC-impedance mode in frequency range 10 to 10 Hz at 0.1 V potential has been carried out. Classification of seven different bottled and municipal drinking water samples along with various tastants dissolved in DI water (DI water) for KCl (5mM) (s...

There is significant interest in the use of electrodes for sensing or actuation in bio-fluidic microsystems. Within these systems high levels of reliability are crucial and complimented by requirements for extremely low levels of false positive and false negatives. This paper extends previous work on impedance and oscillation based condition monitoring of electrode arrays by investigating the a...

A monolithically integrated ISFET sensor array and interface circuit are described. A new high-density, low-power source-drain follower was developed for the sensor array. ISFETs were formed by depositing Au/Ti extended-gate electrodes on standard MOSFETs, then thin silicon nitride layers using catalytic chemical vapor deposition and/or SU-8 protective layers were formed on the extended-gate el...

A bioelectronic system composed of two modified electrodes, one activated in the presence of ketone bodies, a biomarker of diabetic ketoacidosis, and another releasing insulin upon receiving a signal, was designed and tested in vitro to operate as a Sense-and-Act device. The functional integration of biomarker-sensing and insulin-releasing electrodes represents a step to a theranostic system wi...

The recent development, behavior and scope of edge plane pyrolytic graphite electrodes in electroanalysis are overviewed. Similarities to, and advantages, over multi-walled CNT modified electrodes are noted and the wide scope of applications, ranging through gas sensing, stripping voltammetry and biosensing, illustrated.

We present here an electrochemical sensor microsystem for the monitoring of pH. The all-polymeric device is comprised of a cyclic olefin copolymer substrate, a 200 nm-thin patterned layer of conductive polymer (PEDOT), and a 70 nm electropolymerized layer of a pH sensitive conductive polymer (polyaniline). The patterning of the fluidic (microfluidic channels) and conductive (wiring and electrod...

In this paper three-dimensional (3-D) suspended helical nanobelts (HNBs) with ultra-high flexibility are assembled by the external field guidance. Electromagnetic (EM) and electrostatic (ES) force by external potential are characterized quantitatively to guide the assembly of HNBs to create force sensing probe. Both ends of HNBs and target electrodes are attached with ferromagnetic metal connec...