Bruxism affects roughly 5-20% of the adult population. It can be defined as a repetitive jaw-muscle activity characterized by clenching or grinding teeth and occur during sleep-related disorder daytime. irreversibly damage dentition restorations also lead to temporomandibular joint disorders headaches.

SSRIs are chemically distinct from traditional antidepressants such as tricyclic, tetracyclic, and monoamine oxidase inhibitors, but they share the same mechanism of action in that selectively potently inhibit serotonin neuronal reuptake while having no or very little effect on norepinephrine, acetylcholine, histamine reuptake. As a result, when compared to other tricyclic tetracyclic antidepre...

DRUGANDTHERAPEUTICS BULLETIN(1993o) Selective Serotonin Reuptake Inhibitors for Depression? Drug and Thera peutics Bulletin, 31, 57-8. —¿ (1993b) Prescribing costs. Drug and Therapeutics Bulletin. 31. 87. ECCLESTON,D. (1993) The economic evaluation of antidepressant drug therapy. British Journal of Psychiatry, 163. 5-6. MACKAY,A. V. P.I1993) Foreword. In A Review of the Selective Serotonin Re...

OBJECTIVES Approximately 40-60% of obsessive-compulsive disorder patients are nonresponsive to serotonin reuptake inhibitors. Genetic markers associated with treatment response remain largely unknown. We aimed (1) to investigate a possible association of serotonergic polymorphisms in obsessive-compulsive disorder patients and therapeutic response to selective serotonin reuptake inhibitors and (...