hemolysis in patients exhibiting a concurrent acute-phase reaction as indicated by increases in C-reactive protein. The sensitivity of haptoglobin at a cutoff of 250 mgfL, however, is somewhat less than in situations where only hemolysis is present (2). Nonetheless, it is apparent that the decline in serum haptoglobin concentrations, owing to its complexing with hemoglobin and eventual removal ...

Background: Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. Objective: To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels ...

Ultracentrifugal studies of the alpha(2)-proteins of normal human serum before and after the addition of hemoglobin have revealed three separate and clearly distinguishable patterns based on the three major serum haptoglobin groups. Isolation of the three haptoglobin hemoglobin complexes disclosed characteristic patterns for each group. The heterozygote was found to possess electrophoretic and ...

BACKGROUND Haptoglobin polymorphism is associated with the prevalence of infections, autoimmune diseases, cardiovascular diseases, and other disorders. Congenital haptoglobin deficiency is associated with anaphylactic transfusion reactions in anhaptoglobinaemic patients with antihaptoglobin antibody. AIMS To investigate haptoglobin genotypic distribution (including the Hp(0) allele) and assoc...

Background: Haptoglobin polymorphism is associated with the prevalence of infections, autoimmune diseases, cardiovascular diseases, and other disorders. Congenital haptoglobin deficiency is associated with anaphylactic transfusion reactions in anhaptoglobinaemic patients with antihaptoglobin antibody. Aims: To investigate haptoglobin genotypic distribution (including the Hp allele) and associat...

1. A procedure for the rapid, accurate estimation of haptoglobin in serum and purified preparations is described, based on the peroxidase activity of haemoglobin in its complexes with haptoglobin. 2. Hydrogen peroxide, guaiacol and methaemoglobin reagents are used, under well-defined conditions which reduce the peroxidase activity of free haemoglobin essentially to zero. The reaction is followe...

toglobin was determined by the method of Ratcliff and Hardwicke (6). Serum haptoglobin concentration in the normal controls was 1439 ± 405 mg/liter; in the cases of pure iron deficiency it was 798 ± 323 mg/liter. In the cord sera the concentration of haptoglobin was 195 ± 112 mg/liter. The patients’ values for serum haptoglobin were clearly (P <0.001) lower than those of normal controls. It is ...

Background: Haptoglobin polymorphism is associated with the prevalence of infections, autoimmune diseases, cardiovascular diseases, and other disorders. Congenital haptoglobin deficiency is associated with anaphylactic transfusion reactions in anhaptoglobinaemic patients with antihaptoglobin antibody. Aims: To investigate haptoglobin genotypic distribution (including the Hp allele) and associat...