Background: Studies have indicated that extraweight and obesity induce chronic inflammation, which can lead to other diseases such as cancers. Objective: To evaluate the effects of two weight-lowering and anti-inflammatory agents including cinnamon, and turmeric, on serum levels of interleukin-17 (IL-17) as a pro-inflammatory cytokine. Methods: In this study, 64 rats were designated in eight...

OBJECTIVE Th17 has been shown to have a pivotal role in the development of arthritis. However, the role of IL-17 in the T cell-independent effector phase has not fully been examined. We investigated whether IL-17 is involved in the effector phase of arthritis by using K/BxN serum-induced arthritis model. METHODS K/BxN serum was transferred into IL-17 knockout (KO) mice, SCID mice and their co...

Bullous pemphigoid (BP) is an inflammatory autoimmune bullous disease involving cytokines and proteases in the process of blister formation. Recently, IL-17 and IL-23 were evidenced in lesional skin and serum of BP patients at time of diagnosis, but their involvement in disease outcome has still not been investigated yet. We then analysed IL-17 and IL-23 serum levels during the first months of ...

conclusions moderate exercise for 8 weeks increased the ifn-γ and decreased the il-17 serum levels in the morphine-dependent rats. for this reason, this type of exercise can improve the function of the immune system during morphine withdrawal syndrome. results after 8 weeks of exercise, a significant increase was observed in the serum ifn-γ level in the ht group (251.17 ± 13.045) in comparison ...

IIH is a condition of raised intracranial pressure of unknown pathogenesis, which is most commonly seen in young overweight women. This study was designed to confirm and extend previous reports by our and other groups showing increased inflammatory cytokine expression in patients with IIH. We analyzed the concentrations of 14 cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-...

The aim: To research differences of interleukin (IL)-17 and IL-23 serum levels in patients with Alzheimer’s disease, vascular dementia mild cognitive impairment. Material methods: Serum IL-17 were measure by ELISA for 15 14 dementia, 30 impairment control individuals without Results: concentrations significantly higher disease (P=0.0023) than control, no significant differences(P=0.4154). Level...

BACKGROUND Inflammatory bowel disease, an autoimmune disease, has two clinical manifestations including Crohn's disease and ulcerative colitis (UC). IL-17 has been the target of intensive research in autoimmune diseases. The influence of Toll like receptor 4 (TLR-4) gene polymorphisms on IL-17 production has also been revealed in UC patients and tissue inflammation in mice. OBJECTIVES To inve...

Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity. Methods We aimed determine the risk association of hyperinsulinemia in NMOSD patients seropositive AQP4-IgG and serum levels interleukin (IL)-6 IL-17A compared control group. Serum metabolic (Insul...