BACKGROUND Various findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy. The objective of this study was to evaluate the relationships between serum uric acid level and level of proteinuria in type 2 diabetic (T2D) patients. MATERIALS AND METHODS A cross-sectional analytical study was conducted i...

BACKGROUND Elevated albuminuria as well as an increased serum uric acid concentration is associated with poor cardiovascular outcome. We questioned whether these 2 variables (albuminuria and serum uric concentration) may be interrelated via tubular uric acid reabsorption. METHODS AND RESULTS Included were 7688 participants of the PREVEND Study, an observational, general population-based cohor...

background: we aimed to estimate the glomerular filtration rate (gfr) in women with polycystic ovary syndrome (pcos) and to determine the relationship between gfr with c-reactive protein (crp) and uric acid. materials and methods: in this cross-sectional study, one-hundred and forty pcos women and 60 healthy subjects were evaluated. the study was carried out at endocrinology outpatient clinic, ...

BACKGROUND There is evidence that high uric acid is a negative prognostic factor in patients with mild to severe heart failure. A study showed a close correlation between serum uric acid concentration and Killip classification in patients of acute myocardial infarction. MATERIAL AND METHODS We studied 100 patients with acute myocardial infarction and 50 controls. Serum uric acid level was mea...

OBJECTIVES SLC2A9 gene variants associate with serum uric acid in white populations, but little is known about African American populations. Since SLC2A9 is a transporter, gene variants may be expected to associate more closely with the fractional excretion of urate, a measure of renal tubular transport, than with serum uric acid, which is influenced by production and extrarenal clearance. ME...

The relationships between serum uric acid, serum glucose and diabetes have been examined in a survey of 7735 middle-aged men drawn at random from general practices in 24 British towns. There was a positive relationship between serum glucose and serum uric acid concentrations up to about 8.0 mmol/l; at higher levels of glucose, serum uric acid decreased. Uric acid levels were significantly reduc...

Maternal serum uric acid was determined in 30 preeclamptic and 20 normal pregnant females in their third trimester. Serum uric acid was 3.52± 0.75 in normal pregnancies and 6.03 ± 1.67 in preeclamptic pregnancies. This increase in serum uric acid was highly significant (P<0.001). There was no influence of parity and maternal age on serum uric acid. Serum uric acid levels increased significantly...

BACKGROUND Fructose acutely raises serum uric acid in normal subjects, but the effect in subjects with metabolic syndrome or subjects with chronic kidney disease is unknown. The aim of the study was to evaluate changes in serum uric acid during the fructose tolerance test in patients with chronic kidney disease, metabolic syndrome with comparison to healthy controls. METHODS Studies were perf...

OBJECTIVE Uric acid is the end product of purine metabolism in humans, and increased serum uric acid concentrations lead to gout. The objective of the current study was to identify factors that are independently associated with serum uric acid concentrations in a cohort of Czech control individuals. METHODS The cohort consisted of 589 healthy subjects aged 18-65 years. We studied the associat...