OBJECTIVES Genetic factors are extensively studied in respect to drug response in psychiatric disorders. Recent evidence suggests that action of reproductive steroid hormones in brain may also have a role. METHODS Sex-specific differences in terms of illness onset, duration, severity of symptoms and treatment response are well documented. It is believed they result from different brain morpho...

Gonadal steroid hormones act throughout the body to elicit changes in gene expression that result in profound effects on reproductive physiology and behavior. Steroid hormones exert many of these effects by binding to their respective intracellular receptors, which are members of a nuclear receptor superfamily of transcriptional activators. A variety of in vitro studies indicate that nuclear re...

Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic...

INTRODUCTION Few studies have examined how sexual arousal influences healthy premenopausal women's hormones, limiting our understanding of basic physiology and our ability to transfer knowledge from clinical and nonhuman populations. AIM To examine how sexual arousal and steroid hormones (testosterone [T], cortisol [C], estradiol [E]) were linked, to see whether hormone levels influenced and/...

The brain is an important target organ for circulating steroid hormones secreted from peripheral organs such as the adrenal cortex, testis and/or ovary. In other words, these peripheral organs control the central nervous system. Steroid hormones substantially influence brain development, reproduction, sexual differentiation, cognition, memory, behavior, and so on. These effects are mediated by ...

Steroid hormones are extremely important natural in all vertebrates. They control a wide range of physiological processes, including osmoregulation, sexual maturity, reproduction and stress responses. In addition, many synthetic steroid widespread general use, both as human veterinary pharmaceuticals. Recent advances environmental analytical chemistry have enabled concentrations rivers to be de...

It is well established that steroid hormones regulate sexual behavior in vertebrates via organizational and activational effects. However, whether the organizational/activational paradigm applies more broadly to the sexual behavior of other animals such as insects is not well established. Here we describe the hormonal regulation of a sexual behavior in the seasonally polyphenic butterfly Bicycl...

results brdu ihc showed a significant decrease in neurogenesis following tld in both sexes showing more severity in male rats than in female rats. results of nissl staining and mwm also confirmed the brdu findings. regarding sexual dimorphism, our data showed no significant sex differences in the dg area of the hippocampus. conclusions sex-dependent reduction in neurogenesis following tld could...