The Fas/Fas ligand (Fas-L) system has been established as one of the regulatory pathways of apoptotic cell death. Fas is a type I membrane protein which belongs to the tumour necrosis factor/nerve growth factor receptor family and mediates apoptosis. A soluble form of Fas (sFas) found in sera of human subjects is thought to block apoptosis by inhibition of binding between Fas and the antibody t...

Semifluorinated alkanes (SFA, e.g. perfluorobutylpentane F4H5, perfluorohexyloctane F6H8) are inert, non-toxic fluids capable of dissolving lipophilic drugs. The aim of this study to assess the bioavailability and safety of SFAs as drug solvents for the topical ocular application of Cyclosporin A (CsA). A commercially available CsA formulation (Restasis, 0.05% CsA in castor oil) was tested agai...

The aim of this study was to quantify soluble Fas/APO-1 (sFas/APO-1) protein in the serum of patients with Behcet's disease (BD) in active and inactive stages, compared with patients with systemic lupus erythematosus (SLE) and patients with rheumatoid arthritis (RA). Soluble Fas/APO-1 was quantified using a sandwich enzyme-linked immunosorbent assay. Increased serum sFas/APO-1 levels were obser...

Doxorubicin (Dox) is known to cause cardiomyopathy and congestive heart failure upon chronic administration. The mechanisms underlying these toxicities remain uncertain but have been attributed, at least in part, by induction of cardiac cell apoptosis. Fas ligation with its cognate ligand (FasL) induces apoptosis and activates cellular inflammatory responses associated with tissue injury. We de...

  Background: High consumption of fatty acids is known as a dietary risk factor for cardiovascular diseases. The aim of study was to survey of fatty acid profiles in the traditional/fast foods commonly consumed in Iran. Methods: Gas chromatography was used in the present study to determine the composition of fatty acids in 40 most popular traditional/fast foods consumed in Isfahan, Iran. The f...

background: glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. in patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. death of the trabecular meshwork cells may be a result of apoptosis. objective: to investigate the aqueous humor levels of soluble fas (sfas) and fas-ligand (sfasl) in ...

INTRODUCTION Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In the present study, we determined the role of soluble Fas (sFas) in the regulation of posttraumatic neutrophil extrinsic apoptosis and the development of sepsis. METHODS Forty-seven major trauma patients, 18 with and 29 without sepsi...

The Fas/Fas ligand (Fas-L) system has been established as one of the regulatory pathways of apoptotic cell death. Fas is a type I membrane protein which belongs to the tumour necrosis factor/nerve growth factor receptor family and mediates apoptosis. A soluble form of Fas (sFas) found in sera of human subjects is thought to block apoptosis by inhibition of binding between Fas and the antibody t...

Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs) to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. This expert panel reviewed the evidence and reached the following conclusions: the evidence from epidemiologic, clinical, and mechanistic studies is consistent in finding that the risk of CHD is reduced when SFAs a...

BACKGROUND/AIMS The Fas-Fas ligand system is thought to be involved in stromal cell apoptosis after corneal wounding. The aim was to measure changes in human tear fluid levels of soluble Fas (sFas) and Fas ligand (sFasL) following myopic photorefractive keratectomy (PRK). METHODS Tear samples of 59 patients were collected preoperatively, and 1 or 2 days after PRK. Tear fluid sFas or sFasL con...