We investigate the structure of Polchinski’s formulation of the flow equations for the continuum Wilson effective action. Reinterpretations in terms of I.R. cutoff greens functions are given. A promising non-perturbative approximation scheme is derived by carefully taking the sharp cutoff limit and expanding in ‘irrelevancy’ of operators. We illustrate with two simple models of four dimensional...

Shifts in manure phosphorus (P) chemical forms and pool sizes induced by water treatment residuals and industrial mineral by-products are largely undefined. We conducted a manure P fractionation study to determine mechanisms of reduction of dissolved reactive phosphorus (DRP) in poultry manure upon mineral by-product additions. The effects of composting on the P immobilization efficacy of the b...

OBJECTIVES To present a method of comparative mortality analysis of published data that can be applied when age- and sex-specific mortality rates for the study population are not available. METHODS The quantitative method is described and illustrated using data from the SHEP study. A comparison is made with the results of Singer.

CONTEXT In the Systolic Hypertension in the Elderly Program (SHEP) trial, conducted between 1985 and 1990, antihypertensive therapy with chlorthalidone-based stepped-care therapy resulted in a lower rate of cardiovascular events than placebo but effects on mortality were not significant. OBJECTIVE To study the gain in life expectancy of participants randomized to active therapy at the 22-year...

Abstract. Within the framework of the Exact Renormalization Group, a manifestly gauge invariant calculus is constructed for SU(N) Yang-Mills. The methodology is comprehensively illustrated with a proof, to all orders in perturbation theory, that the β function has no explicit dependence on either the seed action or details of the covariantization of the cutoff. The cancellation of these non-uni...

BACKGROUND: Hypertension is among the most common chronic condition in middle-aged and older adults. Approximately 50 million Americans are currently diagnosed with this condition, and more than $18.7 billion is spent on hypertension management, including $3.8 billion for medications. There are numerous pharmacological agents that can be chosen to treat hypertension by physicians in clinical pr...

CECILIA V. ROJAS,1 ALAN NEELY,2 GABRIELA VELASCO-LOYDEN,1 VERÓNICA PALMA,3 AND MANUEL KUKULJAN3 1Instituto de Nutrición y Tecnologı́a de los Alimentos, Universidad de Chile, Casilla 138-11, Santiago; and 3Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Casilla 70005-7, Santiago, Chile; and 2Department of Physiology, Texas Tech University Health Sciences Center, Lubb...

To the Editor: The article by Patel and colleagues relating to long-term follow-up of patients in the SHEP study1 highlights a common problem in vascular prevention trials, namely that the sample size needed to detect an effect on ‘all’ stroke (or the composite of stroke, myocardial infarction, and vascular death) is insufficient to assess effects on fatal events alone. In the case of SHEP, chl...

The CDK inhibitor SNS-032 had previously exerted promising anti-neuroblastoma activity via CDK7 and 9 inhibition. ABCB1 expression was identified as major determinant of SNS-032 resistance. Here, we investigated the role of ABCB1 in acquired SNS-032 resistance. In contrast to ABCB1-expressing UKF-NB-3 sub-lines resistant to other ABCB1 substrates, SNS-032-adapted UKF-NB-3 (UKF-NB-3rSNS- 032300n...