introduction transfusion of red blood cells is a key component in the resuscitation of massively hemorrhaging patients post-injury. little is known about the functional status of patients at discharge or the outcome of patients after discharge from acute hospitalization. we assessed the changes among major trauma patients who had received massive transfusions. materials and methods this article...

OBJECTIVE To compare the intelligence quotient (IQ) of patients with thalassemia major (TM) to that of normal children. METHODS We conducted the study in April and May 2002 on 294 homozygote beta-thalassemia patients, (157 male and 137 female, mean age of 13.2 years; range, 9-18 years). These 294 patients were randomly selected from the 984 TM patients who routinely refer to Shiraz Cooley's M...

INTRODUCTION The early aggressive management of the acute coagulopathy of trauma may improve survival in the trauma population. However, the timely identification of lethal exsanguination remains challenging. This study validated six scoring systems and algorithms to stratify patients for the risk of massive transfusion (MT) at a very early stage after trauma on one single dataset of severely i...

BACKGROUND Massive transfusion of blood products in trauma patients can acutely deplete the blood bank. It was hypothesized that, despite a large allocation of resources to trauma patients receiving more than 50 units of blood products in the first 24 hours, outcome data would support the continued practice of massive transfusion. METHODS A retrospective review of charts and registry data of ...

BACKGROUND Both trauma-induced coagulopathy (TIC) and transfusion strategies influence early outcome in hemorrhagic trauma patients. Their impact on late outcome is less well characterized. This study systematically reviews risk factors for TIC- and transfusion-associated multiple organ failure (MOF) in severely injured trauma patients. MATERIALS AND METHODS A systematic search was conducted ...

BACKGROUND AND AIMS Fluid resuscitation of severely injured patients has shifted over the last decade toward less crystalloids and more blood products. Helsinki University trauma center implemented the massive transfusion protocol in the end of 2009. The aim of the study was to review the changes in fluid resuscitation and its influence on outcome of severely injured patients with hemodynamic c...

BACKGROUND Trauma is the leading cause of loss of life expectancy worldwide. In the most seriously injured patients, coagulopathy is often present on admission. Therefore, transfusion strategies to increase the ratio of plasma (FFP) and platelets (PLT) to red blood cells (RBC), simulating whole blood, have been introduced. Several studies report that higher ratios improve survival in massively ...

OBJECTIVE To evaluate the association of pretrauma center (PTC) red blood cell (RBC) transfusion with outcomes in severely injured patients. BACKGROUND Hemorrhage remains a major driver of mortality. Little evidence exists supporting PTC interventions to mitigate this. METHODS Blunt injured patients in shock arriving at a trauma center within 2 hours of injury were included from the Glue Gr...

Background and aims: Evidence based medicine (EBM) is a systematic process that can lead to enhancement of clinician’s traditional skills in diagnosis and treatment. Teaching EBM to medical students will improve their performance and help them to be up-to-date in their profession. The aim of this study was to compare Shiraz (type 1 university) and Rafsanjan (type 2) students in clinical stage i...

BACKGROUND There are several well established scores for the assessment of the prognosis of major trauma patients that all have in common that they can be calculated at the earliest during intensive care unit stay. We intended to develop a sequential trauma score (STS) that allows prognosis at several early stages based on the information that is available at a particular time. STUDY DESIGN I...