SNP Genotyping In article number 2105538, Jungkyu Choi, Hyojin Lee, Nakwon an co-workers present SWITCH for multiplex single nucleotide polymorphism genotyping. Invaders (single-stranded oligonucleotides, colored in blue and yellow) obtained from a gold nanoparticle induce fluorescence recovery specific regions of shape-coded hydrogel microparticle.

the aims of the present study were to propose apolymerase chain reaction-restriction fragment length polymorphismpcr-rflp genotyping method for the ay_376689:c.773c>t single nucleotide polymorphism snp of the equine prkag3 gene, related to muscle performance, as well as to characterize this snp and a second polymorphism, aawr_02017454:g.121684t>c of the spata1 gene, related to male fertility, i...

background: molecular components of the dopamine receptor (drd3) play an important role in the pathophysiology of schizophrenia (scz). previous studies have demonstrated an association between the drd3 ser9gly polymorphism and scz but the results have been inconclusive. method: in this study, we investigated this controversial association between the ser9gly (a/g) polymorphism and scz using mal...

background coronary artery disease (cad) is the most common cause of death worldwide. mef2a directly regulates target genes in the process of muscle development. this gene product is a transcription factor. mef2a protein in homodimer or heterodimer forms binds to a/t-rich cis elements with conserved sequence in promoter, regulator, and enhancer of many genes, which are determining in evolution ...

Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...

Gene polymorphism refers to a variation in DNA sequence that occurs population with frequency of 1% or higher. Polymorphism may be single nucleotide (SNP) some repetitive sequences (length polymorphism). Several methods can used analyze polymorphism, included Polymerase Chain Reaction (PCR), sequencing from the conventional method more sophisticated such as Next Generation Sequencing (NGS), flu...

Background: We explored the effect of vitamin D receptor gene (VDR) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 μg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels a...

Genetic predisposition without doubt is one of the risk factors cancer initiation. It known that single nucleotide polymorphisms (SNP) genes maintain genome stability, including SNP DNA repair, may contribute to initiation carcinogenesis. Single-nucleotide support repair genes, can Polymorphism excision gene OGG1 causes interest leading scientific groups from various countries. assumed there re...

The present study aims to examine the genetic variation of ATP1B1 gene concerning hypertension and chronic kidney disease CKD. (120 ) blood samples from participants were obtained divided into three groups: a first group representing hypertensive patients (hyper), second Hypertensive CKD (hyper with CKD), third control group. DNA was extracted all then converted cDNA ARMS-PCR technique used inv...