Gemtuzumab ozogamicin (Mylotarg) targets leukemia cells expressing the CD33 receptor by means of a monoclonal antibody conjugated to a cytotoxic agent, calicheamicin. Treatment of acute myeloid leukemia (AML) with gemtuzumab ozogamicin may result in liver injury. We reviewed the course of 23 patients who were given gemtuzumab ozogamicin for AML that had relapsed after hematopoietic cell transpl...

Adhesion of leukocytes to the vascular endothelium hallmarks a key event in neutrophil-mediated organ injury after ischemia-reperfusion. The autacoid adenosine has been shown to inhibit activated neutrophil function and to interfere with leukocyte-endothelial adherence. Its therapeutic use in ischemia-reperfusion, however, has been limited by severe cardiovascular side effects. We therefore inv...

• Simulated DNI informed by real data was applied as a heat flux onto horizontal pipe. Step, sinusoidal, and triangular/ramp waveforms were used. Step reduction resulted in 30% lower transfer coefficient. Sinusoidal triangular reductions an 8% Pressure drop unaffected perturbances. Transient fluxes imposed on solid surfaces can significantly affect the pressure of flow boiling processes diverse...

A method of speech enhancement is developed that reconstructs clean speech from a set of acoustic features using a sinusoidal model of speech. This is a significant departure from traditional filtering-based methods of speech enhancement. A major challenge with this approach is to estimate accurately the acoustic features (voicing, fundamental frequency, spectral envelope) from noisy speech. Th...

In this paper, a modified two-fluid model has been adopted to simulate the process of upward vertical subcooled flow boiling of refrigerant R-113 in a vertical annular channel at low pressure. The modified model considers temperature dependent properties and saturation temperature variation and was validated against a number of published low-pressure subcooled boiling experiments. The results s...

To explore the control of the peripheral circulation of a nonworking upper limb during leg cycling exercise, blood flow (BF) dynamics in the brachial artery (BA) were determined using a sinusoidal work rate (WR) exercise. Ten healthy subjects performed upright leg cycling exercise at a constant WR for 30 min, followed by 16 min of sinusoidal WR consisting of 4-min periods of WR fluctuating betw...

When the renal nerves are stimulated with sinusoidal stimuli over the frequency range 0.04-0.8 Hz, low (< or =0.4 Hz)- but not high (> or =0.4 Hz)-frequency oscillations appear in renal blood flow (RBF) and are proposed to increase responsiveness of the renal vasculature to stimuli. This hypothesis was tested in anesthetized rats in which RBF responses to intrarenal injection of norepinephrine ...

The nonlinear dynamics of and heat and mass transfer processes in annular liquid jets are analyzed by means of a nonlinear system of integrodi€erential equations which account for the liquid motion and the gases enclosed by the jet. Both linear and sinusoidal heat and mass addition sources are considered to take place homogeneously within the volume enclosed by the jet's inner interface in an a...