نتایج جستجو برای: sirtuin 1
تعداد نتایج: 2753772 فیلتر نتایج به سال:
Endocrine society has evidence that plastics can disrupt the endocrine system to cause severe diseases in humans and animals. However, are still used a variety of models for their applications. The overproduction simultaneously increases health hazards human animal living society. pancreas is an produces insulin maintain glucose level blood when resists or does not synthesize causing diabetes m...
Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the applicat...
NAD⁺-dependent histone deacetylases (sirtuins) are implicated in cellular processes such as proliferation, DNA repair, and apoptosis by regulating gene expression and the functions of numerous proteins. Due to their key role in cells, the discovery of small molecule sirtuin modulators has been of significant interest for diverse therapeutic applications. In particular, it has been shown that in...
BACKGROUND Sirtuins are NAD+ dependent deacetylases, which regulate mitochondrial energy metabolism as well as cellular response to stress. The NAD/NADH-system plays a crucial role in oxidative phosphorylation linking sirtuins and the mitochondrial respiratory chain. Furthermore, sirtuins are able to directly deacetylate and activate different complexes of the respiratory chain. This prompted u...
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