the teratogenicity of cadmium exposure was studied in virgin nimri rats aged 10-13 weeks. pregnant animals were fed cadmium sulfate equivalent to doses of 1,4 and 7 mg/kg/day of cadmium by oral gavage on the day 7 of gestation. on the day 18 of gestation, fetuses were delivered and examined for external and skeletal malformations. total percent of malformed fetuses in rats treated by different ...

The objective of this study was to determine microsatellite polymorphism in Rhode Island Red (RIR) and Sussex (SX) chickens, divergently selected over six generations for high (H) or low (L) incidence of skeletal defects in embryos (30.7% for H lines, 3.7% for L lines). The polymorphism analysis covered 15 microsatellite markers within four lines (a total of 60 individuals). Eight alleles were ...

Ten patients with multiple non-ossifying fibromata are reported. All had associated extraskeletal congenital anomalies such as café-au-lait spots, mental retardation, hypogonadism or cryptorchidism, ocular anomalies or cardiovascular malformations. The radiographic picture and the distribution of the skeletal lesions are characteristic and constant. There are lucent areas in the shaft with a sc...

Abstract Background Drug-induced liver damage with clinical symptoms has been related to labetalol in a number of instances. In addition having wide range anti-inflammatory and antioxidant qualities, ginger also includes biotrace that are crucial the fight against disease skeletal deformity. this study, we hypothesized prenatal supplementation (200 mg/kg) attenuates malformation hepatotoxicity ...

Three fundamental types of cephalic axial skeletal-neural dysrapic disorders are analyzed, including: cranioschisis aperta with encephaloschisis (anencephaly and/or exencephaly), cranioschisis occulta with occipital encephalocele, and the Chiari malformation (occipital bone hypoplasia) with compression, deformation and displacement of hindbrain, cerebellum, and medulla. Both clinical and experi...

The development of the axial skeleton is a complex process, consisting of segmentation and differentiation of somites and ossification of the vertebrae. The autosomal recessive skeletal fusion with sterility (sks) mutation of the mouse causes skeletal malformations due to fusion of the vertebrae and ribs, but the underlying defects of vertebral formation during embryonic development have not ye...

Klippel-Trenaunay syndrome (KTS) is a rare complex malformation characterized by the clinical triad of capillary malformations, soft tissue and bone hypertrophy, and venous/lymphatic malformation. Fractures of long bones in such cases are challenging to treat. A 12-year-old female with this syndrome presented with femoral shaft fracture of right thigh. She was initially kept on skeletal tractio...

Hypoplasia of the ischiopubic region is described in four patients. An adolescent was referred for spinal dysraphism and scoliosis, another one for bilateral aplasia of the patella and scoliosis, and finally two children were treated for congenital dislocation of the hip. The osseous malformation of the ischiopubic bones was not associated with any other intrapelvic disorders, and remained unch...

We report a 15-year-old girl who presented with spinal malsegmentation, associated with other skeletal anomalies. The spinal malsegmentation was subsequently discovered to be part of the spondylocarpotarsal synostosis syndrome. In addition, a distinctive craniocervical malformation was identified, which included atlanto-axial rotatory fixation. The clinical and the radiographic findings are des...

Cleidocranial Dysplasia (CCD) or dysostosis is a very rare, under-diagnosed pathology caused by variable degree of expression dominant gene. It characterized skeletal malformations, which can be expressed in different clinical and imagenologic findings, with classic triad; late closure cranial sutures, hypoplasia aplasia clavicles dental abnormalities. We present case 46 years old male, no prev...