enythromycin is believed to cause no serlous reactions after large doses, nausea, rarely vomiting and occasionally abdominal pain and diarrhea may occur, (herrell, 1954). according to' kagan and faller (1955) no allergic reaction to' erythromycin has been reported. phlebitis and thrombosis have been observed, (shoe maker & yow, 1954). in a report by solomon and johnson, (1955) toxic reactions w...

topical and transdermal drug delivery systems are noninvasive and can be self-administered with the minimization of side-effects, have received increased attention during the past few years. nanoemulsions, emulsions sized between 20-200 nm with narrow distributions, offer several advantages for topical and transdermal delivery of pharmaceutical agents including controlled droplet size, the abil...

discussion early recognition of dress syndrome is of a particular importance. although rare, in newborn infants with the presence of skin rash, liver involvement, hyper-eosinophilia and lymphadenopathy, dress diagnosis should be highly suspected and prompt intervention including withdrawal of causative drug is required to prevent potentially fatal outcomes. introduction drug rash with eosinophi...

pathological changes in pulp and periapical tissues are addressed by endodontic treatment. the material used in this treatment must be biocompatible. the aim of this study is to compare the skin reaction of calcium enriched mixture (cem) and mineral trioxide aggregate (mta) produced in iran on rabbit. sixteen male newzeland albino rabbits weighting 2 kg were used. the animals back hair was shav...

Background: Although most cases of drug eruptions are mildand self-limited and are relieved after discontinuation of theresponsible drugs, statistics of life threatening outcomes shouldbe kept in mind. Moreover, it is important to identify the mostcommon age and sex groups, and the most vulnerable groupsin any area related to offending drugs. Thus, we collected thebasic information of patients ...

Cutaneous drug eruptions are one of the most common types of adverse reaction to drug therapy, with an overall incidence rate of 2–3% in hospitalised patients.1–3 Almost any medicine can induce skin reactions, and certain drug classes, such as non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics and antiepileptics, have drug eruption rates approaching 1–5%.4 Although most drug-related sk...

Abstract Drug eruptions are among the most common diseases of skin. The majority cases benign and self-limited, however particular variants very severe potentially life threatening. A precise rapid diagnosis is essential but can be difficult in some instances as drug may lack specific histological criteria. Furthermore, pitfalls frequent heightened awareness to possible mimicry other skin requi...

Severe adverse drug reactions are an important cause of childhood morbidity and mortality. Despite this, few reports in the literature describe it. This study was designed to evaluate the admitted pediatric patients due to adverse drug reactions. This retrospective study was conducted at Pediatric ward of Besat Hospital. The records of hospitalized patients that admitted with diagnosis of adver...

conclusions only a small number of case reports have described valproic acid-induced dress syndrome; therefore, the condition is difficult to prevent. rechallenge with valproic acid should be avoided in patients with a history of reaction to the drug. case presentation we report on the case of a 60-year-old man who had been treated with valproic acid some time before being referred to kowsar ho...

adverse drug reaction (adr) is one of the most life threatening problems, and the economic burden of adr is considerable. the main objective of this study was to assess the attitude of the kerman health system staff, to evaluate their knowledge of the spontaneous reporting system and to identify the reasons for low reporting rate. in this descriptive study, a persian translated questioner was u...