clindamycin is a lincosamide antibiotic which is approved for the treatment of anaerobic, streptococcal and staphylococcal infections. there has been an increased interest in the use of clindamycin since it achieves high intracellular levels in phagocytic cells, high levels in bone and appears to have an antitoxin effect against the toxin elaborating strains of streptococci and staphylococci. c...

The skull base is one of the most complex anatomical regions and forms the floor of the cranial cavity. Skull base surgery involves open, microscopic, and endoscopic approaches to the anterior, middle, or posterior cranial fossa. A multispecialty team approach is essential in treating patients with skull base lesions. Traditionally, rhinologists are involved in providing access to anterior skul...

Skeletal involvement is the second most common site of metastases after lymph nodal metastases in patients with prostate cancer. The skeletal metastases from prostate cancer are osteoblastic in nature and show increased tracer avidity on the bone scan. Focal tracer avid lesion in skeleton especially in skull requires the careful examination by further investigation. The patients with skull meta...

craniosynostoses is defined as a condition of premature fusion in one or more cranial sutures leading to a number of significant complications, mainly raised intracranial pressure which can itself cause other neurodevelopmental complications. copper beaten skull appearance is a well-known presentation of craniosynostoses made by the strong impression of the brain’s gyri on the inner layer of th...

several lesions (inflammatory, neoplastic and congenital) can involve in the skull base. the role of imaging is to detect the location and extension of lesion, determine mass and mass like lesions, differentiate benign from malignant tumors, detect invasion to adjacent structures and make decision in surgical planning. skull base divides to anterior, middle and posterior cranial fossa and some ...

Magnetoencephalography (MEG) signals are influenced by skull defects. However, there is a lack of evidence of this influence during source reconstruction. Our objectives are to characterize errors in source reconstruction from MEG signals due to ignoring skull defects and to assess the ability of an exact finite element head model to eliminate such errors. A detailed finite element model of the...

In this paper we propose a method to include skull inhomogeneities in the EEG forward/inverse calculation by parcellating the skull based on a combination of skull anatomy and thickness. We show that it is enough to determine a few skull parameters (4 6) in the inverse search to capture the skull inhomogeneities if we also include the thickness. The validity of the linear relation between skull...

We used computer simulations to investigate finite element models [1] of the human skull in EEG source analysis. In the first part, we present a systematic investigation on the accuracy of different ways to account for the layered skull structure. We investigated local models, where each skull location was modeled differently, and global models, where the skull was assumed to be homogeneous, bo...

The low-conducting human skull is known to have an especially large influence on electroencephalography (EEG) source analysis. Because of difficulties segmenting the complex skull geometry out of magnetic resonance images, volume conductor models for EEG source analysis might contain inaccuracies and simplifications regarding the geometry of the skull. The computer simulation study presented he...

non-penetrating head injuries associated with skull base fractures can lead to the development of pneumocephalus upon airs ingress, which leads its course in the subarachnoid space. intracerebral air accumulation is rare and ensuses when a paranasal sinus fracture is associated with a ensues when a paranasal sinus fracture is associated with a nearby parenchymal contusion. a 25-year old man is ...